Syringaresinol Alleviates Early Diabetic Retinopathy by Downregulating HIF-1α/VEGF via Activating Nrf2 Antioxidant Pathway,Molecular Nutrition & Food Research

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Syringaresinol Alleviates Early Diabetic Retinopathy by Downregulating HIF-1α/VEGF via Activating Nrf2 Antioxidant Pathway
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-02-14 , DOI: 10.1002/mnfr.202200771
Chang Liu _{1,

2} , Tianwei Cheng ₁ , Yufei Wang ₁ , Guangru Li ₁ , Yachen Wang ₃ , Wencong Tian ₄ , Lifeng Feng ₁ , Shengzheng Zhang ₁ , Yang Xu ₁ , Yang Gao ₁ , Jing Li ₁ , Jie Liu ₁ , Jianlin Cui ₁ , Jie Yan ₁ , Lei Cao ₄ , Zhongjie Pan ₅ , Zhi Qi _{1,

2,

5,

6} , Liang Yang _{1,

5}

Affiliation

Early diabetic retinopathy (DR) is characterized by chronic inflammation, excessive oxidative stress, and retinal microvascular damage. Syringaresinol (SYR), as a natural polyphenolic compound, has been proved to inhibit many disease progression due to its antiinflammatory and antioxidant properties. The present study focuses on exploring the effect of SYR on hyperglycemia-induced early DR as well as the underlying mechanisms.

中文翻译：

丁香树脂醇通过激活 Nrf2 抗氧化途径下调 HIF-1α/VEGF 来减轻早期糖尿病视网膜病变

早期糖尿病视网膜病变（DR）的特点是慢性炎症、过度氧化应激和视网膜微血管损伤。丁香树脂醇 (SYR) 作为一种天然多酚化合物，由于其抗炎和抗氧化特性，已被证明可以抑制许多疾病的进展。本研究重点探讨SYR对高血糖引起的早期DR的影响及其潜在机制。

更新日期：2024-02-14

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