Cytotoxic Polyhydroxy-Isoprenoids from Neodidymelliopsis negundinis,Journal of Natural Products

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Cytotoxic Polyhydroxy-Isoprenoids from Neodidymelliopsis negundinis
Journal of Natural Products ( IF 3.3 ) Pub Date : 2024-02-13 , DOI: 10.1021/acs.jnatprod.3c01094
Patcharee Pripdeevech _{1,

2} , Sarunpron Khruengsai ₁ , Chutima Tanapichatsakul ₁ , Wael M Afifi _{3,

4} , Winnie Chemutai Sum ₅ , Kevin D Hyde _{1,

2} , Sherif S Ebada ₆

Affiliation

Fungal-derived natural products continue to play a pivotal role in the discovery of drug agents for human, veterinary, and general agricultural use. The fungus Neodidymelliopsis negundinis presents a significant saprobic ascomycete whose metabolites remained hitherto unstudied. Herein we report the isolation of eight unprecedented secondary metabolites named neodidymelliosides A and B (1 and 2), neodidymelliol A (3), and neodidymellioic acids A–E (4–8) produced by the submerged cultures of the fungus. Compound 1 proved to be the most active compound, with IC₅₀ values ranging between 4.8 and 8.8 μM against KB3.1 (cervix), PC-3 (prostate), MCF-7 (breast), SKOV-3 (ovary), A431 (skin), and A549 (lung) cell lines. Compound 1 revealed significant inhibition of Staphylococcus aureus and Candida albicans biofilms.

中文翻译：

来自 Neodidymeliopsis negundinis 的细胞毒性多羟基异戊二烯

真菌衍生的天然产物在人类、兽医和一般农业用途的药物发现中继续发挥着关键作用。真菌Neodidymeloliopsis negundinis是一种重要的腐生子囊菌，其代谢物迄今尚未被研究。在此，我们报告了由真菌深层培养物产生的八种前所未有的次级代谢产物，名为新二二甲苷 A 和 B（ 1和2 ）、新二二甲醇 A ( 3 ) 和新二二甲二酸 A–E ( 4 – 8 )。化合物1被证明是最活跃的化合物，针对 KB3.1（子宫颈）、PC-3（前列腺）、MCF-7（乳房）、SKOV-3（卵巢）、A431 的 IC ₅₀值范围为 4.8 至 8.8 μM （皮肤）和 A549（肺）细胞系。化合物1对金黄色葡萄球菌和白色念珠菌生物膜具有显着抑制作用。

更新日期：2024-02-13

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