Polyphenolic Platform Ameliorated Sanshool for Skin Photoprotection,Advanced Science

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Polyphenolic Platform Ameliorated Sanshool for Skin Photoprotection
Advanced Science ( IF 14.3 ) Pub Date : 2024-02-15 , DOI: 10.1002/advs.202310012
Tianyou Wang ₁ , Linghong Guo _{2,

3} , Shuwei Wu _{2,

3} , Yuanyuan Xu _{2,

3} , Junmei Song ₁ , Yi Yang _{2,

3} , Hengjie Zhang ₁ , Dongcui Li ₄ , Yiwen Li ₁ , Xian Jiang _{2,

3} , Zhipeng Gu ₁

Affiliation

Natural evolution has nurtured a series of active molecules that play vital roles in physiological systems, but their further applications have been severely limited by rapid deactivation, short cycle time, and potential toxicity after isolation. For instance, the instability of structures and properties has greatly descended when sanshool is derived from Zanthoxylum xanthoxylum. Herein, natural polyphenols are employed to boost the key properties of sanshool by fabricating a series of nanoparticles (NPs). The intracellular evaluation and in vivo animal model are conducted to demonstrate the decreased photodamage score and skin-fold thickness of prepared NPs, which can be attributed to the better biocompatibility, improved free radical scavenging, down-regulated apoptosis ratios, and reduced DNA double-strand breaks compared to naked sanshool. This work proposes a novel strategy to boost the key properties of naturally occurring active molecules with the assistance of natural polyphenol-based platforms.

中文翻译：

多酚平台改良 Sanshool 用于皮肤光保护

自然进化孕育了一系列在生理系统中发挥重要作用的活性分子，但它们的进一步应用受到快速失活、周期时间短和分离后潜在毒性的严重限制。例如，当山椒素源自花椒时，结构和性质的不稳定性大大降低。在此，利用天然多酚通过制造一系列纳米颗粒 (NP) 来增强山椒素的关键特性。细胞内评估和体内动物模型表明所制备的纳米粒子光损伤评分和皮褶厚度降低，这可归因于更好的生物相容性、改善的自由基清除能力、下调的细胞凋亡率和减少的DNA双链。与裸山椒相比，链断裂。这项工作提出了一种新策略，在天然多酚平台的帮助下增强天然活性分子的关键特性。

更新日期：2024-02-15

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