Reversibly Adhesive, Anti-Swelling, and Antibacterial Hydrogels for Tooth-Extraction Wound Healing,Advanced Healthcare Materials

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Reversibly Adhesive, Anti-Swelling, and Antibacterial Hydrogels for Tooth-Extraction Wound Healing
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2024-02-14 , DOI: 10.1002/adhm.202400089
Siyu Li ₁ , Lunhao Zhi ₁ , Qin Chen ₂ , Weifeng Zhao ₁ , Changsheng Zhao ₁

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Oral wound treatment faces challenges due to the complex oral environment, thus, sealing the wound quickly becomes necessary. Although some materials have achieved adhesion and sterilization, how to effectively solve the contradiction between strong adhesion and on-demand removal remains a challenge. Herein, a reversibly adhesive hydrogel is designed by free radical copolymerization of cationic monomer [2-(acryloyloxy) ethyl] trimethylammonium chloride (ATAC), hydrophobic monomer ethylene glycol phenyl ether acrylate (PEA) and N-isopropylacrylamide (NIPAAm). The cationic quaternary ammonium salts provide electrostatic interactions, the hydrophobic groups provide hydrophobic interactions, and the PNIPAAm chain segments provide hydrogen bonding, leading to strong adhesion. Therefore, the hydrogel obtains an adhesion strength of 18.67 KPa to oral mucosa and can seal wounds fast within 10 s. Furthermore, unlike pure PNIPAAm, the hydrogel has a lower critical solution temperature of 40.3 °C due to the contribution of ATAC and PEA, enabling rapid removal with 40 °C water after treatment. In addition, the hydrogel realizes excellent anti-swelling ratio (≈80%) and antibacterial efficiency (over 90%). Animal experiments prove that the hydrogel effectively reduces inflammation infiltration, promotes collagen deposition and vascular regeneration. Thus, hydrogel as a multi-functional dressing has great application prospects in oral wound management.

中文翻译：

用于拔牙伤口愈合的可逆粘合、抗肿胀和抗菌水凝胶

由于口腔环境复杂，口腔伤口治疗面临挑战，快速封闭伤口成为必要。尽管有些材料已经实现了粘附和灭菌，但如何有效解决强粘附与按需去除之间的矛盾仍然是一个挑战。本文通过阳离子单体[2-(丙烯酰氧基)乙基]三甲基氯化铵(ATAC)、疏水单体乙二醇苯醚丙烯酸酯(PEA)和N-异丙基丙烯酰胺(NIPAAm)的自由基共聚设计了可逆粘合水凝胶。阳离子季铵盐提供静电相互作用，疏水基团提供疏水相互作用，PNIPAAm链段提供氢键，从而产生强粘附力。因此，水凝胶对口腔粘膜的粘附强度为18.67 KPa，可以在10 s内快速密封伤口。此外，与纯PNIPAAm不同，由于ATAC和PEA的贡献，该水凝胶的临界溶液温度较低，为40.3°C，处理后可以用40°C的水快速去除。此外，该水凝胶还实现了优异的抗膨胀率（约80％）和抗菌效率（超过90％）。动物实验证明，该水凝胶有效减少炎症浸润，促进胶原沉积和血管再生。因此，水凝胶作为一种多功能敷料在口腔伤口处理中具有巨大的应用前景。

更新日期：2024-02-14

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