The role of advanced drug delivery strategies in drug repositioning and minimizing drug attrition rates, when applied early in drug discovery, is poised to increase the translational impact of various therapeutic strategies in disease prevention and treatment. In this context, drug delivery to the lymphatic system is gaining prominence not only to improve the systemic bioavailability of various pharmaceutical drugs but also to target certain specific diseases associated with the lymphatic system. Although the role of the lymphatic system in lupus is known, very little is done to target drugs to yield improved clinical benefits. In this review, we discuss recent advances in drug delivery strategies to treat lupus, the various routes of drug administration leading to improved lymph node bioavailability, and the available technologies applied in other areas that can be adapted to lupus treatment. Moreover, this review also presents some recent findings that demonstrate the promise of lymphatic targeting in a preclinical setting, offering renewed hope for certain pharmaceutical drugs that are limited by efficacy in their conventional dosage forms. These findings underscore the potential and feasibility of such lymphatic drug-targeting approaches to enhance therapeutic efficacy in lupus and minimize off-target effects of the pharmaceutical drugs.

中文翻译：

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利用淋巴系统靶向治疗系统性红斑狼疮以改善临床结果


先进的药物递送策略在药物重新定位和最小化药物损耗率方面的作用，在药物发现的早期应用时，有望增加各种治疗策略在疾病预防和治疗中的转化影响。在这种背景下，淋巴系统的药物输送越来越受到重视，不仅可以提高各种药物的全身生物利用度，而且可以针对与淋巴系统相关的某些特定疾病。尽管淋巴系统在狼疮中的作用已为人所知，但针对靶向药物以改善临床疗效的研究却很少。在这篇综述中，我们讨论了治疗狼疮的药物输送策略的最新进展、提高淋巴结生物利用度的各种给药途径，以及适用于狼疮治疗的其他领域的可用技术。此外，本综述还提出了一些最近的发现，这些发现证明了临床前环境中淋巴靶向的前景，为某些因传统剂型的功效而受到限制的药物带来了新的希望。这些发现强调了这种淋巴药物靶向方法在增强狼疮治疗效果并最大限度地减少药物的脱靶效应方面的潜力和可行性。