Noble Metal Nanoparticles with Nanogel Coatings: Coinage Metal Thiolate-Stabilized Glutathione Hydrogel Shells,The Journal of Physical Chemistry C

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Noble Metal Nanoparticles with Nanogel Coatings: Coinage Metal Thiolate-Stabilized Glutathione Hydrogel Shells
The Journal of Physical Chemistry C ( IF 3.3 ) Pub Date : 2024-02-14 , DOI: 10.1021/acs.jpcc.4c00433
Arghyadeep Basu ₁ , Iogann Tolbatov _{2,

3} , Alessandro Marrone ₄ , Alexander Vaskevich ₅ , Lev Chuntonov ₁

Affiliation

Developing biocompatible nanocoatings is crucial for biomedical applications. Noble metal colloidal nanoparticles with biomolecular shells are thought to combine diverse chemical and optothermal functionalities with biocompatibility. Herein, we present nanoparticles with peptide hydrogel shells that feature an unusual combination of properties: the metal core possesses localized plasmon resonance, whereas a few-nanometer-thick shells open opportunities to employ their soft framework for loading and scaffolding. We demonstrate this concept with gold and silver nanoparticles capped by glutathione peptides stacked into parallel β-sheets as they aggregate on the surface. A key role in the formation of the ordered structure is played by coinage metal(I) thiolates, i.e., Ag(I), Cu(I), and Au(I). The shell thickness can be controlled via the concentration of either metal ions or peptides. Theoretical modeling of the shell’s molecular structure suggests that the thiolates have a similar conformation for all the metals and that the parallel β-sheet-like structure is a kinetic product of the peptide aggregation. Using third-order nonlinear two-dimensional infrared spectroscopy, we revealed that the ordered secondary structure is similar to the bulk hydrogels of the coinage metal thiolates of glutathione, which also consist of aggregated stacked parallel β-sheets. We expect that nanoparticles with hydrogel shells will be useful additions to the nanomaterial toolbox. The present method of nanogel coating can be applied to arbitrary surfaces where the initial deposition of the seed glutathione monolayer is possible.

中文翻译：

具有纳米凝胶涂层的贵金属纳米颗粒：造币金属硫醇盐稳定的谷胱甘肽水凝胶壳

开发生物相容性纳米涂层对于生物医学应用至关重要。具有生物分子壳的贵金属胶体纳米颗粒被认为将多种化学和光热功能与生物相容性结合在一起。在此，我们提出了具有肽水凝胶壳的纳米颗粒，其具有不寻常的特性组合：金属核心具有局部等离子体共振，而几纳米厚的壳为利用其软框架进行负载和支架提供了机会。我们用金和银纳米颗粒证明了这一概念，这些纳米颗粒被谷胱甘肽肽覆盖，当它们聚集在表面时，它们堆积成平行的β-片层。造币金属(I)硫醇盐，即Ag(I)、Cu(I)和Au(I)在有序结构的形成中发挥着关键作用。壳厚度可以通过金属离子或肽的浓度来控制。壳分子结构的理论模型表明，硫醇盐对所有金属都具有相似的构象，并且平行的β-片状结构是肽聚集的动力学产物。使用三阶非线性二维红外光谱，我们揭示了有序的二级结构类似于谷胱甘肽的造币金属硫醇盐的块状水凝胶，其也由聚集堆叠的平行β-折叠组成。我们预计具有水凝胶壳的纳米颗粒将成为纳米材料工具箱的有用补充。本发明的纳米凝胶涂层方法可以应用于可以初始沉积种子谷胱甘肽单层的任意表面。

更新日期：2024-02-14

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