Insights into the eradication of drug resistant Staphylococcus aureus via compound 6-nitrobenzo[cd]indole-2(1H)-ketone,Journal of Materials Chemistry B

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Insights into the eradication of drug resistant Staphylococcus aureus via compound 6-nitrobenzo[cd]indole-2(1H)-ketone
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2024-02-14 , DOI: 10.1039/d3tb02686h
Hongshuang Qin ₁ , Lin Li ₁ , Shuhan Chen ₁ , Xuwei Han ₂ , Runan Min ₂ , Yanxiang Guo ₁ , Tao Liu ₃ , Chuanqi Zhao ₄

Affiliation

6-Nitrobenzo[cd]indole-2(1H)-ketone (compound C2) exhibits an excellent germicidal effect against methicillin-resistant Staphylococcus aureus (MRSA). Mechanism studies show that C2 induces ROS over-production, cell membrane damage, and ATP and virulence factor down-regulation in bacteria. More importantly, C2 can inhibit biofilm formation and accelerate wound healing in a mouse infection model induced by MRSA.

中文翻译：

化合物6-硝基苯并[cd]吲哚-2(1H)-酮根除耐药金黄色葡萄球菌的见解

6-硝基苯并[ cd ]吲哚-2( 1H )-酮（化合物C2 ）对耐甲氧西林金黄色葡萄球菌（MRSA）具有优异的杀菌效果。机制研究表明， C2会诱导细菌中 ROS 过量产生、细胞膜损伤以及 ATP 和毒力因子下调。更重要的是，在 MRSA 诱导的小鼠感染模型中， C2可以抑制生物膜形成并加速伤口愈合。

更新日期：2024-02-14

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