Indoline-5-sulfonamide derivatives of benzocaine have been synthesized using a sequence of three reactions: N-acylation, sulfochlorination, sulfonamidation, and their antienteroviral activity has been evaluated. Two compounds, namely, ethyl 4-((1-(cyclobutanecarbonyl)indoline)-5-sulfonamido)benzoate and ethyl 4-((1-benzoylindoline)-5-sulfonamido)benzoate exhibited a medium level of activity against coxsackievirus B3 (Nancy strain) in vitro. Their antiviral potential is exerted upon prophylactic application when added to cell culture before infection with the virus.

中文翻译：

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苯佐卡因-N-酰基吲哚啉缀合物：合成和针对柯萨奇病毒 B3 的抗病毒活性

使用三个反应序列合成了苯佐卡因的二氢吲哚-5-磺酰胺衍生物：N-酰化、磺氯化、磺酰胺化，并评估了它们的抗肠道病毒活性。两种化合物，即 4-((1-(环丁烷羰基)二氢吲哚)-5-磺酰胺基)苯甲酸乙酯和 4-((1-苯甲酰二氢吲哚)-5-磺酰胺基)苯甲酸乙酯，对柯萨奇病毒 B3 表现出中等水平的活性（Nancy菌株）体外。当在感染病毒之前将其添加到细胞培养物中时，它们的抗病毒潜力可在预防性应用时发挥作用。