Cell Membrane Perforation: Patterns, Mechanisms and Functions,Small

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Cell Membrane Perforation: Patterns, Mechanisms and Functions
Small ( IF 13.0 ) Pub Date : 2024-02-12 , DOI: 10.1002/smll.202310605
Xinran Zhu ₁ , Zhifeng Shi ₂ , Ying Mao ₂ , Ulrich Lächelt ₃ , Rongqin Huang ₁

Affiliation

Cell membrane is crucial for the cellular activities, and any disruption to it may affect the cells. It is demonstrated that cell membrane perforation is associated with some biological processes like programmed cell death (PCD) and infection of pathogens. Specific developments make it a promising technique to perforate the cell membrane controllably and precisely. The pores on the cell membrane provide direct pathways for the entry and exit of substances, and can also cause cell death, which means reasonable utilization of cell membrane perforation is able to assist intracellular delivery, eliminate diseased or cancerous cells, and bring about other benefits. This review classifies the patterns of cell membrane perforation based on the mechanisms into 1) physical patterns, 2) biological patterns, and 3) chemical patterns, introduces the characterization methods and then summarizes the functions according to the characteristics of reversible and irreversible pores, with the aim of providing a comprehensive summary of the knowledge related to cell membrane perforation and enlightening broad applications in biomedical science.

中文翻译：

细胞膜穿孔：模式、机制和功能

细胞膜对于细胞活动至关重要，任何对其的破坏都可能影响细胞。研究表明，细胞膜穿孔与程序性细胞死亡（PCD）和病原体感染等一些生物过程有关。具体的发展使其成为一种有前途的可控且精确地对细胞膜进行穿孔的技术。细胞膜上的孔洞为物质的进出提供了直接的途径，也可以导致细胞死亡，这意味着合理利用细胞膜穿孔可以辅助细胞内的输送，消除病变或癌细胞等带来的好处。本文根据细胞膜穿孔的机制将细胞膜穿孔的模式分为1）物理模式、2）生物模式和3）化学模式，介绍了表征方法，然后根据可逆和不可逆孔的特点总结了其功能，目的是对细胞膜穿孔相关知识进行全面总结，并启发在生物医学科学中的广泛应用。

更新日期：2024-02-12

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