Effective tobacco policies are important for reducing the harm of tobacco use and can have a broad impact at the population level. This review provides an overview of how clinical science can inform tobacco policies with a focus on policies related to flavored tobacco products, using menthol cigarettes as an illustrative example. Specifically, this review summarizes the role of flavors in tobacco use and the history of regulation of flavored tobacco products by the US Food and Drug Administration (FDA), provides an overview of clinical research methods used to contribute to the scientific evidence to inform FDA tobacco policies, discusses key findings related to menthol tobacco products using these methods, and proposes future directions for clinical research. As the tobacco marketplace continues to evolve with new products and flavor chemicals, ongoing clinical science will be essential for establishing evidence-based policies to protect public health and reduce tobacco-related health disparities.

中文翻译：

---

烟草制品中风味调控的科学依据


有效的烟草政策对于减少烟草使用的危害非常重要，并且可以在人口层面产生广泛影响。本综述概述了临床科学如何为烟草政策提供信息，重点是与调味烟草制品相关的政策，以薄荷醇卷烟为例。具体来说，本综述总结了香料在烟草使用中的作用以及美国食品和药物管理局 （FDA） 对调味烟草制品的监管历史，概述了用于为 FDA 烟草政策提供科学证据的临床研究方法，讨论了使用这些方法与薄荷醇烟草制品相关的主要发现， 并提出了临床研究的未来方向。随着烟草市场不断推出新产品和风味化学品，持续的临床科学对于制定循证政策以保护公众健康和减少与烟草相关的健康差异至关重要。