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Nanotherapeutics for Alleviating Anesthesia-Associated Complications
Advanced Science ( IF 14.3 ) Pub Date : 2024-02-11 , DOI: 10.1002/advs.202308241 Bin Lu 1, 2 , Ling Wei 3 , Gaoxiang Shi 1 , Jiangfeng Du 2, 4
Advanced Science ( IF 14.3 ) Pub Date : 2024-02-11 , DOI: 10.1002/advs.202308241 Bin Lu 1, 2 , Ling Wei 3 , Gaoxiang Shi 1 , Jiangfeng Du 2, 4
Affiliation
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Current management of anesthesia-associated complications falls short in terms of both efficacy and safety. Nanomaterials with versatile properties and unique nano-bio interactions hold substantial promise as therapeutics for addressing these complications. This review conducts a thorough examination of the existing nanotherapeutics and highlights the strategies for developing prospective nanomedicines to mitigate anesthetics-related toxicity. Initially, general, regional, and local anesthesia along with the commonly used anesthetics and related prevalent side effects are introduced. Furthermore, employing nanotechnology to prevent and alleviate the complications of anesthetics is systematically demonstrated from three aspects, that is, developing 1) safe nano-formulization for anesthetics; 2) nano-antidotes to sequester overdosed anesthetics and alter their pharmacokinetics; 3) nanomedicines with pharmacodynamic activities to treat anesthetics toxicity. Finally, the prospects and challenges facing the clinical translation of nanotherapeutics for anesthesia-related complications are discussed. This work provides a comprehensive roadmap for developing effective nanotherapeutics to prevent and mitigate anesthesia-associated toxicity, which can potentially revolutionize the management of anesthesia complications.
中文翻译：
减轻麻醉相关并发症的纳米疗法
目前对麻醉相关并发症的管理在有效性和安全性方面均不足。具有多功能特性和独特的纳米生物相互作用的纳米材料作为解决这些并发症的治疗方法具有巨大的前景。本综述对现有的纳米疗法进行了彻底的检查，并强调了开发前瞻性纳米药物以减轻麻醉剂相关毒性的策略。首先，介绍全身麻醉、区域麻醉和局部麻醉以及常用的麻醉剂和相关的常见副作用。此外，还从三个方面系统地论证了利用纳米技术预防和减轻麻醉药并发症，即开发1）安全的麻醉药纳米制剂； 2) 纳米解毒剂，用于隔离过量的麻醉剂并改变其药代动力学； 3）具有药效活性的纳米药物治疗麻醉药物毒性。最后，讨论了纳米疗法临床转化用于麻醉相关并发症所面临的前景和挑战。这项工作为开发有效的纳米疗法以预防和减轻麻醉相关毒性提供了全面的路线图，这可能会彻底改变麻醉并发症的管理。
更新日期：2024-02-12
中文翻译：
减轻麻醉相关并发症的纳米疗法
目前对麻醉相关并发症的管理在有效性和安全性方面均不足。具有多功能特性和独特的纳米生物相互作用的纳米材料作为解决这些并发症的治疗方法具有巨大的前景。本综述对现有的纳米疗法进行了彻底的检查，并强调了开发前瞻性纳米药物以减轻麻醉剂相关毒性的策略。首先，介绍全身麻醉、区域麻醉和局部麻醉以及常用的麻醉剂和相关的常见副作用。此外，还从三个方面系统地论证了利用纳米技术预防和减轻麻醉药并发症，即开发1）安全的麻醉药纳米制剂； 2) 纳米解毒剂，用于隔离过量的麻醉剂并改变其药代动力学； 3）具有药效活性的纳米药物治疗麻醉药物毒性。最后，讨论了纳米疗法临床转化用于麻醉相关并发症所面临的前景和挑战。这项工作为开发有效的纳米疗法以预防和减轻麻醉相关毒性提供了全面的路线图，这可能会彻底改变麻醉并发症的管理。
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