Facile Preparation of Polysarcosine-Tethered Inorganic Nanospheres by Using Unimolecular Polypept(o)ides as Template,Small Methods

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Facile Preparation of Polysarcosine-Tethered Inorganic Nanospheres by Using Unimolecular Polypept(o)ides as Template
Small Methods ( IF 10.7 ) Pub Date : 2024-02-11 , DOI: 10.1002/smtd.202301424
Xikuang Yao ₁ , Linhui Hao ₁ , Ting Wang ₁ , Fei Xiong ₁ , Qian Shen ₁ , Wei Huang _{1,

2,

3}

Affiliation

Polymer-inorganic nanocomposites that integrate the advantages of both polymers and inorganic nanoparticles (NPs) are broadly exploited for versatile applications. Especially, emerging polymer-templated preparation of inorganic NPs has drawn extensive attention, which is ascribed to simplified synthesis and feasible tunability. However, how to precisely fabricate biocompatible polymer-inorganic NPs remains unsolved. In this article, by mild ring opening polymerization (ROP) of β-benzyl L-aspartate N-carboxyanhydrides (BLA-NCAs) and sarcosine N-carboxyanhydrides (Sar-NCAs) and subsequent debenzylation, a series of poly(amino acid)-based unimolecular micelles (PAMAM-g-(PLA-b-PSar)) are facilely synthesized. Afterward, by utilization of these star-like polymers as template, the controllable preparation of various PSar-tethered inorganic NPs is investigated and characterized meticulously. This general strategy for the preparation of PSar-tethered inorganic NPs can bring a great chance for future fabrication of biomedical nanoplatforms.

中文翻译：

以单分子Polypept（o）ides为模板简便制备Polysarcosine-Tethered无机纳米球

聚合物-无机纳米复合材料结合了聚合物和无机纳米颗粒（NP）的优点，被广泛用于多种应用。特别是新兴的无机NPs聚合物模板化制备引起了广泛关注，这归因于简化的合成和可行的可调性。然而，如何精确制备生物相容性聚合物-无机 NPs 仍未解决。在本文中，通过β-苄基 L-天冬氨酸 N-羧酐（BLA-NCA）和肌氨酸 N-羧酐（Sar-NCA）的温和开环聚合（ROP）和随后的脱苄化，很容易合成一系列基于聚（氨基酸）的单分子胶束（PAMAM-g-（PLA-b-PSar））。然后，利用这些星状聚合物作为模板，对各种 PSar 束缚无机NPs的可控制备进行了细致的研究和表征。这种制备 PSar 束缚无机纳米 NP 的通用策略可以为未来生物医学纳米平台的制备带来巨大的机会。

更新日期：2024-02-11

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