Single-Component Photochemical Afterglow Near-Infrared Luminescent Nano-Photosensitizers: Bioimaging and Photodynamic Therapy,Advanced Healthcare Materials

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Single-Component Photochemical Afterglow Near-Infrared Luminescent Nano-Photosensitizers: Bioimaging and Photodynamic Therapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2024-02-09 , DOI: 10.1002/adhm.202304392
Yin Li ₁ , Dong He ₂ , Qiangfeng Zheng ₁ , Ruilin Tang ₁ , Qing Wan _{1,

3} , Ben Zhong Tang ₄ , Zhiming Wang ₁

Affiliation

Long afterglow luminescence-guided photodynamic therapy (PDT) performs advantages of noninvasiveness, spatiotemporal controllability, and higher signal to noise ratio. Photochemical afterglow (PCA) system emitting afterglow in an aqueous environment is highly suitable for biomedical applications, but still faces the challenges of poor tissue penetration depth and responsive sensitivity. In this work, two novel compounds, Iso-TPA and ABEI-TPA, are designed and synthesized to integrate the PCA system as a single component by coupling near-infrared (NIR) photosensitizers with singlet oxygen cache units, respectively. Both compounds emit NIR afterglow based on photochemical reaction. ABEI-TPA exhibits higher photoluminescence quantum efficiency with nonconjugated linkage, while Iso-TPA with conjugated linkage possesses better reactive oxygen species generation efficiency to achieve stronger PCA and effective PDT, which is ascribed to stronger intramolecular charge transfer effect of Iso-TPA. Iso-TPA nanoparticles can achieve effective long-lasting NIR afterglow in vivo bioimaging up to 120 s with higher imaging resolution and outstanding PDT efficacy of tumor, exhibiting promising potential on bioimaging and therapy.

中文翻译：

单组分光化学余辉近红外发光纳米光敏剂：生物成像和光动力治疗

长余辉发光引导光动力治疗（PDT）具有无创、时空可控、信噪比高等优点。在水环境中发射余辉的光化学余辉（PCA）系统非常适合生物医学应用，但仍然面临组织穿透深度和响应灵敏度较差的挑战。在这项工作中，设计并合成了两种新型化合物 Iso-TPA 和 ABEI-TPA，通过分别将近红外 (NIR) 光敏剂与单线态氧缓存单元耦合，将 PCA 系统集成为单个组件。两种化合物均基于光化学反应发出近红外余辉。非共轭键的ABEI-TPA表现出更高的光致发光量子效率，而共轭键的Iso-TPA具有更好的活性氧生成效率，从而实现更强的PCA和有效的PDT，这归因于Iso-TPA更强的分子内电荷转移效应。 Iso-TPA纳米颗粒可实现长达120秒的有效长效近红外余辉体内生物成像，具有更高的成像分辨率和出色的肿瘤PDT疗效，在生物成像和治疗方面展现出广阔的潜力。

更新日期：2024-02-09

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