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Nanoplastics Affect the Bioaccumulation and Gut Toxicity of Emerging Perfluoroalkyl Acid Alternatives to Aquatic Insects (Chironomus kiinensis): Importance of Plastic Surface Charge
ACS Nano ( IF 15.8 ) Pub Date : 2024-02-07 , DOI: 10.1021/acsnano.3c12009 Jie Zhang 1 , Xinghui Xia 1 , Chuanxin Ma 2 , Shangwei Zhang 3 , Kaixuan Li 1 , Yingying Yang 1 , Zhifeng Yang 1, 2
ACS Nano ( IF 15.8 ) Pub Date : 2024-02-07 , DOI: 10.1021/acsnano.3c12009 Jie Zhang 1 , Xinghui Xia 1 , Chuanxin Ma 2 , Shangwei Zhang 3 , Kaixuan Li 1 , Yingying Yang 1 , Zhifeng Yang 1, 2
Affiliation
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Persistent organic pollutants (POPs) have been widely suggested as contributors to the aquatic insect biomass decline, and their bioavailability is affected by engineered particles. However, the toxicity effects of emerging ionizable POPs mediated by differentially charged engineered nanoparticles on aquatic insects are unknown. In this study, 6:2 chlorinated polyfluoroalkyl ether sulfonate (F-53B, an emerging perfluoroalkyl acid alternative) was selected as a model emerging ionizable POP; the effect of differentially charged nanoplastics (NPs, 50 nm, 0.5 g/kg) on F-53B bioaccumulation and gut toxicity to Chironomus kiinensis were investigated through histopathology, biochemical index, and gut microbiota analysis. The results showed that when the dissolved concentration of F-53B remained constant, the presence of NPs enhanced the adverse effects on larval growth, emergence, gut oxidative stress and inflammation induced by F-53B, and the enhancement caused by positively charged NP-associated F-53B was stronger than that caused by the negatively charged one. This was mainly because positively charged NPs, due to their greater adsorption capacity and higher bioavailable fraction of associated F-53B, increased the bioaccumulation of F-53B in larvae more significantly than negatively charged NPs. In addition, positively charged NPs interact more easily with gut biomembranes and microbes with a negative charge, further increasing the probability of F-53B interacting with gut biomembranes and microbiota and thereby aggravating gut damage and key microbial dysbacteriosis related to gut health. These findings demonstrate that the surface charge of NPs can regulate the bioaccumulation and toxicity of ionizable POPs to aquatic insects.
中文翻译：
纳米塑料影响新兴全氟烷基酸替代水生昆虫（摇蚊）的生物累积和肠道毒性：塑料表面电荷的重要性
持久性有机污染物（POP）被广泛认为是导致水生昆虫生物量下降的因素，其生物利用度受到工程颗粒的影响。然而，由带不同电荷的工程纳米粒子介导的新兴电离持久性有机污染物对水生昆虫的毒性作用尚不清楚。本研究选择6:2氯化多氟烷基醚磺酸盐（F-53B，一种新兴的全氟烷基酸替代品）作为新兴电离POP的模型；通过组织病理学、生化指标和肠道微生物群分析，研究了带不同电荷的纳米塑料（NP，50 nm，0.5 g/kg）对 F-53B 生物蓄积和摇蚊肠道毒性的影响。结果表明，当F-53B的溶解浓度保持恒定时，NP的存在增强了F-53B对幼虫生长、羽化、肠道氧化应激和炎症的不利影响，以及带正电荷的NP相关的增强作用。 F-53B 比带负电的 F-53B 造成的强度更强。这主要是因为带正电的纳米颗粒由于其更大的吸附能力和更高的相关 F-53B 生物利用度分数，比带负电的纳米颗粒更显着地增加了幼虫中 F-53B 的生物积累。此外，带正电荷的纳米粒子更容易与带负电荷的肠道生物膜和微生物相互作用，进一步增加F-53B与肠道生物膜和微生物群相互作用的可能性，从而加剧肠道损伤和与肠道健康相关的关键微生物菌群失调。这些发现表明，纳米颗粒的表面电荷可以调节可电离持久性有机污染物对水生昆虫的生物累积和毒性。
更新日期：2024-02-07
中文翻译：
纳米塑料影响新兴全氟烷基酸替代水生昆虫（摇蚊）的生物累积和肠道毒性：塑料表面电荷的重要性
持久性有机污染物（POP）被广泛认为是导致水生昆虫生物量下降的因素，其生物利用度受到工程颗粒的影响。然而，由带不同电荷的工程纳米粒子介导的新兴电离持久性有机污染物对水生昆虫的毒性作用尚不清楚。本研究选择6:2氯化多氟烷基醚磺酸盐（F-53B，一种新兴的全氟烷基酸替代品）作为新兴电离POP的模型；通过组织病理学、生化指标和肠道微生物群分析，研究了带不同电荷的纳米塑料（NP，50 nm，0.5 g/kg）对 F-53B 生物蓄积和摇蚊肠道毒性的影响。结果表明，当F-53B的溶解浓度保持恒定时，NP的存在增强了F-53B对幼虫生长、羽化、肠道氧化应激和炎症的不利影响，以及带正电荷的NP相关的增强作用。 F-53B 比带负电的 F-53B 造成的强度更强。这主要是因为带正电的纳米颗粒由于其更大的吸附能力和更高的相关 F-53B 生物利用度分数，比带负电的纳米颗粒更显着地增加了幼虫中 F-53B 的生物积累。此外，带正电荷的纳米粒子更容易与带负电荷的肠道生物膜和微生物相互作用，进一步增加F-53B与肠道生物膜和微生物群相互作用的可能性，从而加剧肠道损伤和与肠道健康相关的关键微生物菌群失调。这些发现表明，纳米颗粒的表面电荷可以调节可电离持久性有机污染物对水生昆虫的生物累积和毒性。
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