<br>具有类 SOD 酶活性的多功能 Cu2Se/F127 水凝胶可有效促进伤口愈合,Advanced Healthcare Materials

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具有类 SOD 酶活性的多功能 Cu2Se/F127 水凝胶可有效促进伤口愈合
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2024-02-08 , DOI: 10.1002/adhm.202303599
Jia He ₁ , Wei Zhang ₂ , Yuyu Cui ₁ , Liang Cheng ₃ , Xu-Lin Chen ₁ , Xianwen Wang _{2,

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Affiliation

皮肤损伤后会分泌自由基，引起氧化应激和炎症反应，增加伤口愈合的难度。本研究通过阴离子交换策略合成了铜基纳米酶Cu ₂ Se纳米片（NSs），并将其应用于F127水凝胶的伤口，以研究这种纳米酶复合水凝胶对伤口的愈合效果。 Cu ₂ Se NSs具有大量的催化活性中心，合成简单，反应条件少，合成周期短。体外实验表明，Cu ₂ Se NSs具有类超氧化物歧化酶（SOD）活性和氮自由基清除活性，可促进血管生成和成纤维细胞迁移。 Cu ₂ Se NSs 掺杂到 F127 水凝胶中不会对水凝胶的性能产生显着影响。这种杂化水凝胶不仅能适应急性伤口不规则、复杂的形态，还能延长纳米酶对伤口的作用持续时间，从而促进伤口愈合。转录组分析进一步揭示了 Cu ₂ Se/F127 水凝胶促进急性伤口愈合的潜在治疗机制。动物实验表明Cu ₂ Se/F127水凝胶具有良好的生物安全性。 Cu ₂ Se/F127水凝胶为开发用于治疗急性伤口的水凝胶敷料提供了创新思路。

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Multifunctional Cu2Se/F127 Hydrogel with SOD-Like Enzyme Activity for Efficient Wound Healing

Free radicals are secreted following skin damage and cause oxidative stress and inflammatory reactions that increase the difficulty of wound healing. In this study, copper-based nanozyme Cu₂Se nanosheets (NSs) are synthesized by an anion-exchange strategy and apply to wounds with F127 hydrogels to investigate the healing effect of this nanozyme composite hydrogels on wounds. Cu₂Se NSs have a large number of catalytically active centers, are simple to synthesize, require few reaction conditions and have a short synthesis cycle. In vitro experiments have shown that Cu₂Se NSs possess superoxide dismutase (SOD)-like activity and nitrogen radical scavenging activity and promote angiogenesis and fibroblast migration. The doping of Cu₂Se NSs into the F127 hydrogel does not have a significantly affect on the properties of the hydrogel. This hybridized hydrogel not only adapts to the irregular and complex morphology of acute wounds but also prolongs the duration of nanozyme action on the wound, thus promoting wound healing. Transcriptomic analysis further reveals the potential therapeutic mechanism of the Cu₂Se/F127 hydrogel in promoting acute wound healing. Animal experiments have shown that the Cu₂Se/F127 hydrogel has good biosafety. The Cu₂Se/F127 hydrogel provides an innovative idea for the development of hydrogel dressings for the treatment of acute wounds.

更新日期：2024-02-08

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