当前位置：
X-MOL 学术
›
ACS Mater. Lett.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Multivalence Manganese Mediated Dual ROS Generator for Augmented Chemodynamic Therapy and Activated Antitumor Immunogenic Responses
ACS Materials Letters ( IF 9.6 ) Pub Date : 2024-02-08 , DOI: 10.1021/acsmaterialslett.3c01459
Linlin Huo 1 , Shiqi Zhu 1 , Jie Zeng 1 , Ruipeng Lin 2 , Wenwen Chen 2 , Muyao Li 3 , Xin Sun 4 , Mingya Tan 1 , Guoming Huang 2 , Kai Xu 5 , Zhenghuan Zhao 1
ACS Materials Letters ( IF 9.6 ) Pub Date : 2024-02-08 , DOI: 10.1021/acsmaterialslett.3c01459
Linlin Huo 1 , Shiqi Zhu 1 , Jie Zeng 1 , Ruipeng Lin 2 , Wenwen Chen 2 , Muyao Li 3 , Xin Sun 4 , Mingya Tan 1 , Guoming Huang 2 , Kai Xu 5 , Zhenghuan Zhao 1
Affiliation
|
The efficacy of chemodynamic therapy (CDT) and its potential to induce immunogenic cell death (ICD) are highly dependent on the types and efficiency of generated reactive oxygen species (ROS). Herein, we innovatively develop a manganese platinum (MnPt) nanozyme with dual ROS generation for magnetic resonance imaging guided CDT and ICD. The multivalence state of Mn ions authorizes MnPt to simultaneously generate hydroxyl radical and singlet oxygen under high H2O2 and acid condition, which obviously increases the types of ROS. Significantly, the mild photothermal conversion and enzyme-like activity endow MnPt to regulate tumor microenvironment and elevate the operating rate, further increasing the ROS generation efficiency and CDT efficacy in vitro/vivo. Moreover, the exaltation on both types and generation efficiency of ROS significantly enhances immunogenicity and initiates the immune response to limit tumor metastases. This study provides a highly practical strategy for the accurate diagnosis and efficient therapy of tumors.
中文翻译：
多价锰介导的双 ROS 发生器，用于增强化学动力学治疗和激活抗肿瘤免疫原性反应
化学动力学疗法（CDT）的功效及其诱导免疫原性细胞死亡（ICD）的潜力高度依赖于产生的活性氧（ROS）的类型和效率。在此，我们创新性地开发了一种具有双ROS生成功能的锰铂（MnPt）纳米酶，用于磁共振成像引导的CDT和ICD。Mn离子的多价态使得MnPt在高H 2 O 2和酸性条件下同时产生羟基自由基和单线态氧，从而明显增加了ROS的种类。值得注意的是，温和的光热转换和类酶活性赋予MnPt调节肿瘤微环境并提高运转率，进一步提高体外/体内ROS生成效率和CDT功效。此外，ROS类型和生成效率的提高显着增强了免疫原性并启动免疫反应以限制肿瘤转移。该研究为肿瘤的准确诊断和有效治疗提供了高度实用的策略。
更新日期：2024-02-08
中文翻译：
多价锰介导的双 ROS 发生器，用于增强化学动力学治疗和激活抗肿瘤免疫原性反应
化学动力学疗法（CDT）的功效及其诱导免疫原性细胞死亡（ICD）的潜力高度依赖于产生的活性氧（ROS）的类型和效率。在此，我们创新性地开发了一种具有双ROS生成功能的锰铂（MnPt）纳米酶，用于磁共振成像引导的CDT和ICD。Mn离子的多价态使得MnPt在高H 2 O 2和酸性条件下同时产生羟基自由基和单线态氧，从而明显增加了ROS的种类。值得注意的是，温和的光热转换和类酶活性赋予MnPt调节肿瘤微环境并提高运转率，进一步提高体外/体内ROS生成效率和CDT功效。此外，ROS类型和生成效率的提高显着增强了免疫原性并启动免疫反应以限制肿瘤转移。该研究为肿瘤的准确诊断和有效治疗提供了高度实用的策略。
京公网安备 11010802027423号