To study the relationships between stromal cell-derived factor-1 (SDF-1ɑ) and renal cell carcinoma (RCC) susceptibility and the presence of single nucleotide polymorphisms in the human X-ray cross-complementary repair gene (XRCC1). Compare SDF-1 based on RCC related data in the TCGA database α, The expression difference of XRCC1 between RCC tissue and normal tissue; Collect 166 newly diagnosed RCC cases and 166 healthy individuals who underwent physical examinations during the same period, and detect genotype using iMLDR method. The results The rs1801157 locus (C:T) of the SDF-1α gene was not significantly associated with the pathohistological type, the rs1799782 locus (G:A) of the XRCC1 gene was associated with the pathohistological type of RCC, and there were interactions between rs1799782 and smoking, alcohol consumption, pesticide exposure, hair dye, and urine holding. The rs1799782 locus of the XRCC1 gene may be a key factor in the pathogenesis and pathological development of RCC. High SDF-1ɑ expression is a protective factor for the overall survival of patients with RCC, and SDF-1ɑ and XRCC1 may be important for the treatment of RCC.

研究基质细胞衍生因子-1 (SDF-1ɑ) 与肾细胞癌 (RCC) 易感性之间的关系以及人类 X 射线交叉互补修复基因 (XRCC1) 中单核苷酸多态性的存在。根据TCGA数据库中RCC相关数据比较SDF-1α，RCC组织与正常组织中XRCC1的表达差异；收集166例初诊RCC病例和同期体检的166名健康者，采用iMLDR方法检测基因型。结果 SDF-1α基因的rs1801157位点（C：T）与RCC的病理类型无显着相关性，XRCC1基因的rs1799782位点（G：A）与RCC的病理类型相关，且存在交互作用rs1799782 与吸烟、饮酒、接触杀虫剂、染发剂和憋尿之间的关系。 XRCC1基因的rs1799782位点可能是RCC发病和病理发展的关键因素。 SDF-1ɑ高表达是RCC患者总生存的保护因素，SDF-1ɑ和XRCC1可能对RCC的治疗很重要。