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Phytochemicals from the Stem Bark of Calophyllum havilandii P. F. Stevens and their Biological Activities
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2024-01-24 , DOI: 10.1002/cbdv.202301936 Ahmad Alif Danial Zailan 1 , Thiruventhan Karunakaran 1, 2 , Rameshkumar Santhanam 3 , Amira Suriaty Yaakop 4 , Sivakumar Mohan 3 , Mohamad Hafizi Abu Bakar 5 , Vivien Jong Yi Mian 6
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2024-01-24 , DOI: 10.1002/cbdv.202301936 Ahmad Alif Danial Zailan 1 , Thiruventhan Karunakaran 1, 2 , Rameshkumar Santhanam 3 , Amira Suriaty Yaakop 4 , Sivakumar Mohan 3 , Mohamad Hafizi Abu Bakar 5 , Vivien Jong Yi Mian 6
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The genus Calophyllum from the family Calophyllaceae has been extensively investigated in the past due to its rich source of bioactive phenolics such as coumarins, chromanones, and xanthones. In this study, phytochemical investigation on the stem bark of Calophyllum havilandii has afforded a new 4-propyldihydrocoumarin derivative, havilarin (1) together with calolongic acid (2), caloteysmannic acid (3), isocalolongic acid (4), euxanthone (5), and β-sitosterol (6). The chemical structure of compound 1 was elucidated and established based on detailed spectroscopic techniques, including MS, IR, UV, 1D and 2D NMR. The results of anti-bacillus study indicated that the chloroform extract showed promising activities with MIC value ranging between 0.5 to 1 μg/mL on selected bacillus strains. Besides, the plant extracts and compounds 1–4 were assessed for their cytotoxicity potential on HL-7702 cell line. All the tested plant extracts and respective chemical constituents displayed non-cytotoxic activity on HL-7702 cell line.
中文翻译：
哈维兰茎皮的植物化学物质及其生物活性
由于香豆素、色满酮和氧杂蒽酮等生物活性酚类物质的丰富来源，来自Calophyllaceae科的Calophyllum属在过去已被广泛研究。在这项研究中，对海藻茎皮进行的植物化学研究提供了一种新的 4-丙基二氢香豆素衍生物，哈维拉林(1)以及 calolongic Acid ( 2 )、caloteysmannic Acid ( 3 )、isocalolongic Acid ( 4 )、euxanthone ( 5 )和β-谷甾醇( 6 )。基于详细的光谱技术，包括 MS、IR、UV、1D 和 2D NMR，阐明并建立了化合物1的化学结构。抗杆菌研究结果表明，氯仿提取物对选定的杆菌菌株显示出良好的活性，MIC 值在 0.5 至 1 μg/mL 之间。此外，还评估了植物提取物和化合物1-4对 HL-7702 细胞系的潜在细胞毒性。所有测试的植物提取物和各自的化学成分均对 HL-7702 细胞系表现出非细胞毒性活性。
更新日期：2024-01-24
中文翻译：
哈维兰茎皮的植物化学物质及其生物活性
由于香豆素、色满酮和氧杂蒽酮等生物活性酚类物质的丰富来源，来自Calophyllaceae科的Calophyllum属在过去已被广泛研究。在这项研究中，对海藻茎皮进行的植物化学研究提供了一种新的 4-丙基二氢香豆素衍生物，哈维拉林(1)以及 calolongic Acid ( 2 )、caloteysmannic Acid ( 3 )、isocalolongic Acid ( 4 )、euxanthone ( 5 )和β-谷甾醇( 6 )。基于详细的光谱技术，包括 MS、IR、UV、1D 和 2D NMR，阐明并建立了化合物1的化学结构。抗杆菌研究结果表明，氯仿提取物对选定的杆菌菌株显示出良好的活性，MIC 值在 0.5 至 1 μg/mL 之间。此外，还评估了植物提取物和化合物1-4对 HL-7702 细胞系的潜在细胞毒性。所有测试的植物提取物和各自的化学成分均对 HL-7702 细胞系表现出非细胞毒性活性。
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