One-pot Twostep Chemobiocatalytic Synthesis of a Furan Amino Acid from 5-Hydroxymethylfurfural,Chemistry - A European Journal

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One-pot Twostep Chemobiocatalytic Synthesis of a Furan Amino Acid from 5-Hydroxymethylfurfural
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2024-02-08 , DOI: 10.1002/chem.202400269
Zi-Cheng Wu ₁ , Wei-Wei Li ₁ , Min-Hua Zong ₁ , Ning Li ₁

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A chemobiocatalytic tandem process toward 5-aminomethyl-2-furancarboxylic acid (AMFC) was developed by combining laccase-TEMPO system and a whole-cell catalyst in a single reaction vessel, starting from 5-hydroxymethylfurfural (HMF) and inexpensive ammonium formate. The desired product was obtained with 81 % yield. More importantly, the scale-up production of AMFC was demonstrated, with 0.41 g/L h productivity.

中文翻译：

5-羟甲基糠醛一锅两步化学生物催化合成呋喃氨基酸

通过在单个反应容器中结合漆酶-TEMPO系统和全细胞催化剂，以5-羟甲基糠醛（HMF）和廉价的甲酸铵为原料，开发了一种制备5-氨甲基-2-呋喃甲酸（AMFC）的化学生物催化串联工艺。获得所需产物，收率81%。更重要的是，AMFC的放大生产得到了证明，生产率为0.41 g/L h。

更新日期：2024-02-08

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