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Polydopamine-Coated Self-Assembled Lipid Nanoparticles for Highly Effective Chemo–Photothermal Combination Therapy
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2024-02-06 , DOI: 10.1021/acs.iecr.3c04310
Yuansheng Li 1 , Yu Cheng 2 , Yuankun Wu 1 , Zixi Wang 1 , Xiang Ma 3 , Jian Zhao 1 , Ziyi Yang 4 , Yuanhui Ji 1
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2024-02-06 , DOI: 10.1021/acs.iecr.3c04310
Yuansheng Li 1 , Yu Cheng 2 , Yuankun Wu 1 , Zixi Wang 1 , Xiang Ma 3 , Jian Zhao 1 , Ziyi Yang 4 , Yuanhui Ji 1
Affiliation
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Chemo–photothermal combination therapy is an emerging clinical treatment method, which shows favorable application prospects in clinical practice. However, various drug delivery systems have certain disadvantages, and it is urgent to overcome the existing disadvantages and combine the advantages of different delivery systems. In this study, we have designed and synthesized a novel core–shell polymer-coated lipid-core nanoparticle drug delivery system for chemo–photothermal therapy. The designed drug delivery system is based on electrostatic self-assembled polylysine-lecithin (PLL-LC) lipid nanoparticles to encapsulate antitumor or anti-inflammatory drugs and then coated with polydopamine (PDA) shell for chemo–photothermal combination therapy. The self-polymerized PDA coated on the surface of nanomicelles under weak alkaline conditions can form a responsive drug delivery system. As expected, the prepared core–shell nanoparticles showed good photothermal properties and good potential for thermal ablation of tumor cells. Moreover, the release of chemotherapeutic drugs under the modification of polydopamine has the corresponding pH and NIR stimulation. In vitro drug release and cell experiments demonstrated that our designed nanoparticles could achieve pH- and NIR-stimulation-responsive drug release and exhibit enhanced tumor cytotoxicity under laser irradiation. Taken together, our study demonstrates that designed nanoparticles can be used for pH/NIR-responsive sustained release and chemo–photothermal synergistic treatment.
中文翻译：
用于高效化疗-光热联合治疗的聚多巴胺涂层自组装脂质纳米颗粒
化疗-光热联合治疗是一种新兴的临床治疗方法，在临床中显示出良好的应用前景。然而，各种药物递送系统都存在一定的缺点，迫切需要克服现有的缺点并结合不同递送系统的优点。在这项研究中，我们设计并合成了一种用于化学光热治疗的新型核壳聚合物包覆的脂质核纳米颗粒药物递送系统。设计的药物递送系统基于静电自组装聚赖氨酸-卵磷脂（PLL-LC）脂质纳米颗粒，封装抗肿瘤或抗炎药物，然后涂有聚多巴胺（PDA）外壳，用于化疗-光热联合治疗。自聚合的PDA在弱碱性条件下包覆在纳米胶束表面可形成响应性药物递送系统。正如预期的那样，制备的核壳纳米粒子表现出良好的光热性能和热消融肿瘤细胞的良好潜力。而且，聚多巴胺修饰下化疗药物的释放具有相应的pH和NIR刺激。体外药物释放和细胞实验表明，我们设计的纳米颗粒可以实现 pH 和近红外刺激响应的药物释放，并在激光照射下表现出增强的肿瘤细胞毒性。综上所述，我们的研究表明，设计的纳米颗粒可用于 pH/NIR 响应的持续释放和化学光热协同治疗。
更新日期：2024-02-06
中文翻译：
用于高效化疗-光热联合治疗的聚多巴胺涂层自组装脂质纳米颗粒
化疗-光热联合治疗是一种新兴的临床治疗方法，在临床中显示出良好的应用前景。然而，各种药物递送系统都存在一定的缺点，迫切需要克服现有的缺点并结合不同递送系统的优点。在这项研究中，我们设计并合成了一种用于化学光热治疗的新型核壳聚合物包覆的脂质核纳米颗粒药物递送系统。设计的药物递送系统基于静电自组装聚赖氨酸-卵磷脂（PLL-LC）脂质纳米颗粒，封装抗肿瘤或抗炎药物，然后涂有聚多巴胺（PDA）外壳，用于化疗-光热联合治疗。自聚合的PDA在弱碱性条件下包覆在纳米胶束表面可形成响应性药物递送系统。正如预期的那样，制备的核壳纳米粒子表现出良好的光热性能和热消融肿瘤细胞的良好潜力。而且，聚多巴胺修饰下化疗药物的释放具有相应的pH和NIR刺激。体外药物释放和细胞实验表明，我们设计的纳米颗粒可以实现 pH 和近红外刺激响应的药物释放，并在激光照射下表现出增强的肿瘤细胞毒性。综上所述，我们的研究表明，设计的纳米颗粒可用于 pH/NIR 响应的持续释放和化学光热协同治疗。
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