Front Cover. EGFR and VEGFR-2 are commonly overexpressed in cancers making them attractive targets for cancer therapy. Hydrazone and oxadiazole derivatives of indole-6-carboxylic acid, targeting EGFR and VEGFR-2, respectively, were synthesized to improve lack of selectivity of chemotherapeutic agents. The new derivatives with antiproliferation activity through the induction of the extrinsic apoptosis pathway were presented by M. Allawi et al. in their research article at 10.1002/cbdv.202301892.

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封面：新型吲哚 6 羧酸衍生物作为多靶点抗增殖剂：合成、计算机研究和细胞毒性评估（化学生物多样性 2/2024）

封面。EGFR 和 VEGFR-2 在癌症中通常过度表达，这使得它们成为癌症治疗的有吸引力的靶点。合成了分别针对 EGFR 和 VEGFR-2 的吲哚-6-羧酸腙和恶二唑衍生物，以改善化疗药物选择性的缺乏。M. Allawi 等人提出了通过诱导外源性细胞凋亡途径而具有抗增殖活性的新衍生物。在他们的研究文章 10.1002/cbdv.202301892 中。