Metabolic reprogramming directed by super-enhancers in tumors: An emerging landscape,Molecular Therapy

当前位置： X-MOL 学术 › Mol. Ther. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Metabolic reprogramming directed by super-enhancers in tumors: An emerging landscape
Molecular Therapy ( IF 12.1 ) Pub Date : 2024-02-06 , DOI: 10.1016/j.ymthe.2024.02.003
Zongjiang Zhou ₁ , Jinghe Li ₂ , Diabate Ousmane ₂ , Li Peng ₃ , Xiaoqing Yuan ₃ , Junpu Wang ₄

Affiliation

Department of Pathology, Xiangya Hospital, Central South University, Changsha, China; Department of Pathology, School of Basic Medicine, Central South University, Changsha, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Department of Pathology, Xiangya Hospital, Central South University, Changsha, China; Department of Pathology, School of Basic Medicine, Central South University, Changsha, China.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Department of Pathology, Xiangya Hospital, Central South University, Changsha, China; Department of Pathology, School of Basic Medicine, Central South University, Changsha, China; Ultrapathology (Biomedical Electron Microscopy) Center, Department of Pathology, Xiangya Hospital, Central South University, Changsha, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Metabolic reprogramming is an essential hallmark of tumors, and metabolic abnormalities are strongly associated with the malignant phenotype of tumor cells. This is closely related to transcriptional dysregulation. Super-enhancers are extremely active -regulatory regions in the genome, and can amalgamate a complex set of transcriptional regulatory components that are crucial for establishing tumor cell identity, promoting tumorigenesis, and enhancing aggressiveness. In addition, alterations in metabolic signaling pathways are often accompanied by changes in super-enhancers. Presently, there is a surge in interest in the potential pathogenesis of various tumors through the transcriptional regulation of super-enhancers and oncogenic mutations in super-enhancers. In this review, we summarize the functions of super-enhancers, oncogenic signaling pathways, and tumor metabolic reprogramming. In particular, we focus on the role of the super-enhancer in tumor metabolism and its impact on metabolic reprogramming. This review also discusses the prospects and directions in the field of super-enhancer and metabolic reprogramming.

中文翻译：

肿瘤中超级增强子指导的代谢重编程：一个新兴的前景

代谢重编程是肿瘤的重要标志，代谢异常与肿瘤细胞的恶性表型密切相关。这与转录失调密切相关。超级增强子是基因组中极其活跃的调节区域，可以融合一组复杂的转录调节组分，这些组分对于建立肿瘤细胞身份、促进肿瘤发生和增强侵袭性至关重要。此外，代谢信号通路的改变通常伴随着超级增强子的变化。目前，人们对通过超级增强子的转录调控和超级增强子中的致癌突变来研究各种肿瘤的潜在发病机制的兴趣激增。在这篇综述中，我们总结了超级增强子、致癌信号通路和肿瘤代谢重编程的功能。特别是，我们关注超级增强子在肿瘤代谢中的作用及其对代谢重编程的影响。本文还讨论了超级增强子和代谢重编程领域的前景和方向。

更新日期：2024-02-06

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南