This study developed ten novel acetohydrazide hybrid compounds containing furfuryloxy-1,2,3-triazole rings, evaluating their inhibitory effects on key enzymes (hAChE, hBChE, hCAI, and hCAII) involved in physiological processes. Compounds 9 demonstrated strong inhibitory activity against these enzymes, with low IC₅₀ values, making them promising inhibitors for neurological and metabolic processes. In silico studies provided insights into their binding interactions with proteins.

中文翻译：

---

作为胆碱酯酶和碳酸酐酶抑制剂的 4-糠氧基甲基-1,2,3-三唑-1-基-乙酰肼杂化物：合成、表征和综合生物活性研究

本研究开发了十种含有糠氧基-1,2,3-三唑环的新型乙酰肼杂化化合物，评估了它们对参与生理过程的关键酶（hAChE、hBChE、hCAI 和 hCAII）的抑制作用。化合物 9对这些酶表现出强抑制活性，IC ₅₀值低，使其成为神经和代谢过程的有前途的抑制剂。计算机研究提供了对其与蛋白质的结合相互作用的见解。