Research and development of new antibacterial agents are desperately needed in modern medicine, particularly ones that can effectively combat multi-resistant bacteria. Herein, we report the synthesis of a new series of substituted 4-phenylthiazolyl-1,3,5-triazine derivatives and their physicochemical characterization using IR, mass, and ¹H-NMR spectroscopy. Among the synthesized derivatives examined for antibacterial activity, one compound 6-chloro-N-(4-dimethylamino-phenyl)-N′-[4-(4-methoxy-phenyl)-thiazol-2-yl]-[1,3,5]-triazine-2,4-di-amine (SK4) demonstrated encouraging inhibition of both Gram-positive and Gram-negative bacteria compared with the standard drug ofloxacin. Another compound 4-(4,6-dichloro-1,3,5-triazine-2-yl)amino-benzoic acid (SK1) also exhibited significant antimicrobial activity against S. aureus. Apotential drug target, DNA gyrase, was found to be the most suitable for these molecules using molecular docking. Identified new hits are crucial for both antimicrobial stewardship and the prevention of antimicrobial resistance in the future.

现代医学迫切需要研发新型抗菌药物，特别是能够有效对抗多重耐药菌的抗菌药物。在此，我们报告了一系列新的取代的 4-苯基噻唑基-1,3,5-三嗪衍生物的合成及其使用红外、质谱和¹ H-NMR 光谱的物理化学表征。在检测抗菌活性的合成衍生物中，一种化合物 6-氯-N- (4-二甲氨基-苯基) -N '-[4-(4-甲氧基-苯基)-噻唑-2-基]-[1,3与标准药物氧氟沙星相比，5]-三嗪-2,4-二胺 (SK4) 对革兰氏阳性菌和革兰氏阴性菌具有令人鼓舞的抑制作用。另一种化合物4-(4,6-二氯-1,3,5-三嗪-2-基)氨基苯甲酸(SK1)也对金黄色葡萄球菌表现出显着的抗菌活性。通过分子对接发现，潜在的药物靶标 DNA 旋转酶最适合这些分子。确定的新打击对于未来抗菌药物管理和预防抗菌药物耐药性至关重要。