Abstract

In search for new compounds capable of overcoming antimicrobial resistance, we synthesized a series of previously unknown 1-[(2-aryl-5-(pyridine-4-yl)-1,3,4-oxadiazol-3(2H)-yl]-3-(pyridine-2-yl)prop-2-en-1-ones and assessed their composition and structures using elemental analysis, FTIR, ¹H NMR, and ¹³C NMR spectroscopy, and mass spectrometry. The synthesized compounds were screened for antibacterial activity to show that 1-[2-(3-fluorophenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl])-3-(pyridin-2-yl)prop-2-en-1-one and 1-[2-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]-3-(pyridin-2-yl)prop-2-en-1-one were effective against C. albicans and A. clavatus fungal strains, while 1-[(2-phenyl-5-(pyridine-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-3-(pyridine-2-yl)prop-2-en-1-one and 1-[2-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]-3-(pyridin-2-yl)prop-2-en-1-one demonstrated activity against E. coli and P. aeruginosa bacterial strains.

中文翻译：

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新型吡啶 1,3,4-恶二唑衍生物：合成、表征和抗菌筛选

摘要

为了寻找能够克服抗菌素耐药性的新化合物，我们合成了一系列以前未知的 1-[(2-aryl-5-(pyridine-4-yl)-1,3,4-oxadiazol-3(2 H )- yl]-3-(吡啶-2-基)丙-2-en-1-酮，并使用元素分析、FTIR、¹ H NMR、¹³ C NMR 光谱和质谱评估了它们的组成和结构。筛选抗菌活性，结果显示 1-[2-(3-氟苯基)-5-(吡啶-4-基)-1,3,4-恶二唑-3(2 H )-基])-3-(吡啶-2-基)丙-2-en-1-酮和1-[2-(4-氟苯基)-5-(吡啶-4-基)-1,3,4-恶二唑-3(2 H ) -yl]-3-(pyridin-2-yl)prop-2-en-1-one 对白色念珠菌和棒曲霉真菌菌株有效，而 1-[(2-苯基-5-(吡啶-4) -基)-1,3,4-恶二唑-3(2H ) -基)-3-(吡啶-2-基)丙-2-en-1-酮和1-[2-(4-氟苯基) -5-(吡啶-4-基)-1,3,4-恶二唑-3(2 H )-基]-3-(吡啶-2-基)丙-2-en-1-酮表现出抗E的活性. 大肠杆菌和铜绿假单胞菌菌株。