Recent advances of nanopore technique in single cell analysis,Analyst

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Recent advances of nanopore technique in single cell analysis
Analyst ( IF 3.6 ) Pub Date : 2024-02-05 , DOI: 10.1039/d3an01973j
Xue Zhang ₁ , Zhuoqun Su ₁ , Yan Zhao ₁ , Di Wu ₂ , Yongning Wu _{1,

3} , Guoliang Li ₁

Affiliation

Single cells and their dynamic behavior are closely related to biological research. Monitoring their dynamic behavior is of great significance for disease prevention. How to achieve rapid and non-destructive monitoring of single cells is a major issue that needs to be solved urgently. As an emerging technology, nanopores have been proven to enable non-destructive and label-free detection of single cells. The structural properties of nanopores enable a high degree of sensitivity and accuracy during analysis. In this article, we summarize and classify the different types of solid-state nanopores that can be used for single-cell detection and illustrate their specific applications depending on the size of the analyte. In addition, their research progress in material transport and microenvironment monitoring is also highlighted. Finally, a brief summary of existing research challenges and future trends in nanopore single-cell analysis is tentatively provided.

中文翻译：

纳米孔技术在单细胞分析中的最新进展

单细胞及其动态行为与生物学研究密切相关。监测其动态行为对于疾病预防具有重要意义。如何实现对单细胞的快速、无损监测是亟待解决的重大问题。作为一项新兴技术，纳米孔已被证明能够实现单细胞的无损、无标记检测。纳米孔的结构特性使得分析过程具有高度的灵敏度和准确性。在本文中，我们对可用于单细胞检测的不同类型的固态纳米孔进行了总结和分类，并根据分析物的大小说明了它们的具体应用。此外，他们在物质传输和微环境监测方面的研究进展也得到了重点关注。最后，初步总结了纳米孔单细胞分析的现有研究挑战和未来趋势。

更新日期：2024-02-05

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