Electrochemical Ni-Catalyzed Decarboxylative C(sp3)−N Cross-Electrophile Coupling,Angewandte Chemie International Edition

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Electrochemical Ni-Catalyzed Decarboxylative C(sp3)−N Cross-Electrophile Coupling
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-02-01 , DOI: 10.1002/anie.202315222
Yue-Ming Cai ₁ , Xiao-Ting Liu ₁ , Lin-Lin Xu ₁ , Ming Shang ₁

Affiliation

Ni-catalyzed decarboxylative C(sp³)−N cross-coupling of redox active ester and oxime esters was realized through electrochemical cathodic reduction. Mechanistic studies unveil a high-valent nickel species-driven reductive elimination pathway, rather than direct radical-radical coupling. The utility of this methodology was demonstrated through a broad scope (1°, 2°, 3° carboxylic acids) and late-stage functionalization of complex molecules.

中文翻译：

电化学 Ni 催化脱羧 C(sp3)−N 交叉电偶联

通过电化学阴极还原实现了氧化还原活性酯和肟酯的镍催化脱羧C(sp ³ )−N交叉偶联。机理研究揭示了高价镍物质驱动的还原消除途径，而不是直接的自由基-自由基耦合。该方法的实用性通过复杂分子的广泛范围（1°、2°、3°羧酸）和后期功能化得到了证明。

更新日期：2024-02-01

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