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Soil health hazards of di(2-ethylhexyl) phthalate: New perspectives on earthworms from different ecological niches DNA damage, gut microbial disruption and soil enzyme changes
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2024-02-03 , DOI: 10.1016/j.jhazmat.2024.133700 Xianxu Li 1 , Nan Jiang 2 , Juan Zhang 3 , Xiangfeng Yao 1 , Wenrong Liu 1 , Qian Wang 1 , Jia Ding 1 , Zhuran Hu 4 , Lusheng Zhu 1 , Jinhua Wang 1 , Jun Wang 1
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2024-02-03 , DOI: 10.1016/j.jhazmat.2024.133700 Xianxu Li 1 , Nan Jiang 2 , Juan Zhang 3 , Xiangfeng Yao 1 , Wenrong Liu 1 , Qian Wang 1 , Jia Ding 1 , Zhuran Hu 4 , Lusheng Zhu 1 , Jinhua Wang 1 , Jun Wang 1
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Di(2-ethylhexyl) phthalate (DEHP) is perceived an emerging threat to terrestrial ecosystem, however, clear and accurate studies to fully understander ecotoxicity and underlying mechanisms of DEHP on the soil fauna remain poorly understood. Therefore, this study conducted a microcosm experiment of two earthworm ecotypes to investigate the ecological hazards of DHEP from multiple perspectives. The results showed that DEHP significantly increased the 8-hydroxy-deoxyguanosine (8-OHdG) content both in (13.76–133.0%) and (11.01–49.12%), leading to intracellular DNA damage. Meanwhile, DEHP negatively affected the expression of functional genes (, ), which may be detrimental to mitochondrial respiration and oxidative stress at the gene level. The two earthworm guts shared analogous dominant bacteria however, the incorporation of DEHP drastically suppressed the homogeneity and diversity of the gut microbes, which further disrupted the homeostasis of the gut microbial ecological network. The keystone species in the gut of decreased under DEHP stress but increased in the gut of . Moreover, DEHP presented detrimental effects on soil enzyme activity, which is mainly associated with pollutant levels and earthworm activity. Collectively, the findings expand the understanding of soil ecological health and reveal the underlying mechanisms of the potential exposure risk to DEHP.
中文翻译：
邻苯二甲酸二（2-乙基己基）酯对土壤健康的危害：不同生态位蚯蚓的新视角 DNA 损伤、肠道微生物破坏和土壤酶变化
邻苯二甲酸二(2-乙基己基)酯 (DEHP) 被认为是对陆地生态系统的新威胁，然而，对于充分了解 DEHP 对土壤动物的生态毒性和潜在机制的清晰、准确的研究仍然知之甚少。因此，本研究对两种蚯蚓生态型进行了微观实验，从多个角度探讨DHEP的生态危害。结果表明，DEHP显着增加了（13.76-133.0%）和（11.01-49.12%）的8-羟基脱氧鸟苷（8-OHdG）含量，导致细胞内DNA损伤。同时，DEHP对功能基因的表达产生负面影响（，），这可能在基因水平上不利于线粒体呼吸和氧化应激。两条蚯蚓肠道具有相似的优势菌群，然而DEHP的掺入极大地抑制了肠道微生物的同质性和多样性，进一步破坏了肠道微生物生态网络的稳态。 DEHP 胁迫下肠道中的关键物种减少，但肠道中的关键物种增加。此外，DEHP 对土壤酶活性产生不利影响，这主要与污染物水平和蚯蚓活性有关。总的来说，这些发现扩大了对土壤生态健康的理解，并揭示了 DEHP 潜在暴露风险的潜在机制。
更新日期：2024-02-03
中文翻译：
邻苯二甲酸二（2-乙基己基）酯对土壤健康的危害：不同生态位蚯蚓的新视角 DNA 损伤、肠道微生物破坏和土壤酶变化
邻苯二甲酸二(2-乙基己基)酯 (DEHP) 被认为是对陆地生态系统的新威胁，然而，对于充分了解 DEHP 对土壤动物的生态毒性和潜在机制的清晰、准确的研究仍然知之甚少。因此，本研究对两种蚯蚓生态型进行了微观实验，从多个角度探讨DHEP的生态危害。结果表明，DEHP显着增加了（13.76-133.0%）和（11.01-49.12%）的8-羟基脱氧鸟苷（8-OHdG）含量，导致细胞内DNA损伤。同时，DEHP对功能基因的表达产生负面影响（，），这可能在基因水平上不利于线粒体呼吸和氧化应激。两条蚯蚓肠道具有相似的优势菌群，然而DEHP的掺入极大地抑制了肠道微生物的同质性和多样性，进一步破坏了肠道微生物生态网络的稳态。 DEHP 胁迫下肠道中的关键物种减少，但肠道中的关键物种增加。此外，DEHP 对土壤酶活性产生不利影响，这主要与污染物水平和蚯蚓活性有关。总的来说，这些发现扩大了对土壤生态健康的理解，并揭示了 DEHP 潜在暴露风险的潜在机制。
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