<br>优先生物降解石膏纤维赋予隐形微孔结构并增强磷酸钙骨水泥的成骨能力,ACS Biomaterials Science & Engineering

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优先生物降解石膏纤维赋予隐形微孔结构并增强磷酸钙骨水泥的成骨能力
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2024-02-01 , DOI: 10.1021/acsbiomaterials.3c01574
Yan Zhang ₁ , Lijun Xie ₂ , Xiaoyi Jiao ₃ , Xusong Yue ₃ , Yan Xu ₁ , Cong Wang ₂ , Yifan Li ₄ , Xianyan Yang ₁ , Guojing Yang ₃ , Sanzhong Xu ₄ , Yingjie Wang ₅ , Xisheng Weng ₅ , Zhongru Gou ₁

Affiliation

众所周知，羟基磷灰石型磷酸钙骨水泥（CPC）显示出明显的自固化性能，但相变产物往往导致缓慢的生物降解和令人失望的成骨反应。在此，我们开发了一种赋予隐形微孔网络的创新策略，该策略可以通过石膏纤维调节α-磷酸三钙（α-TCP）基CPC的微观结构和生物降解，并且可以增强复合水泥的体内成骨能力。通过将石膏粉/羧化壳聚糖（CC）浆料通过22G喷嘴（直径410μm）挤出并用钙盐溶液收集来制备石膏纤维。然后，通过将 α-TCP 粉末与石膏纤维（0-24 wt%）和水溶液混合形成自固化水泥来制备 CPC。物理化学特性表明，随着纤维含量的增加，可注射性降低。 μCT重建表明石膏纤维可以分布在CPC基底中并产生长距离的微孔结构。特别是，掺入石膏纤维可以调节离子释放，在体外产生隧道状孔隙网络，并在体内促进兔股骨缺损的新骨组织再生。适当的石膏纤维（16 和 24 wt%）可以增强骨缺损修复和水泥生物降解。这些结果表明，高度可生物降解的水泥纤维可以调节传统 CPC 生物材料的微观结构，这种双组分复合策略可能有利于扩大基于 CPC 的临床应用。

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Preferentially Biodegradable Gypsum Fibers Endowing Invisible Microporous Structures and Enhancing Osteogenic Capability of Calcium Phosphate Cements

It is known that hydroxyapatite-type calcium phosphate cement (CPC) shows appreciable self-curing properties, but the phase transformation products often lead to slow biodegradation and disappointing osteogenic responses. Herein, we developed an innovative strategy to endow invisible micropore networks, which could tune the microstructures and biodegradation of α-tricalcium phosphate (α-TCP)-based CPC by gypsum fibers, and the osteogenic capability of the composite cements could be enhanced in vivo. The gypsum fibers were prepared via extruding the gypsum powder/carboxylated chitosan (CC) slurry through a 22G nozzle (410 μm in diameter) and collecting with a calcium salt solution. Then, the CPCs were prepared by mixing the α-TCP powder with gypsum fibers (0–24 wt %) and an aqueous solution to form self-curing cements. The physicochemical characterizations showed that injectability was decreased with an increase in the fiber contents. The μCT reconstruction demonstrated that the gypsum fiber could be distributed in the CPC substrate and produce long-range micropore architectures. In particular, incorporation of gypsum fibers would tune the ion release, produce tunnel-like pore networks in vitro, and promote new bone tissue regeneration in rabbit femoral bone defects in vivo. Appropriate gypsum fibers (16 and 24 wt %) could enhance bone defect repair and cement biodegradation. These results demonstrate that the highly biodegradable cement fibers could mediate the microstructures of conventional CPC biomaterials, and such a bicomponent composite strategy may be beneficial for expanding clinical CPC-based applications.

更新日期：2024-02-01

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