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Stable iron (58Fe) isotopic measurements in Kenyan toddlers during 3 months of iron supplementation demonstrate that half of the iron absorbed is lost
British Journal of Haematology ( IF 5.1 ) Pub Date : 2024-02-01 , DOI: 10.1111/bjh.19319 Ambra Giorgetti 1, 2 , Suzane Nyilima 3 , Nicole U Stoffel 1, 2 , Diego Moretti 4 , Edith Mwasi 5 , Simon Karanja 3 , Christophe Zeder 1 , Cornelia Speich 1 , Catalina Netland 1 , Zhezhen Jin 6 , Michael B Zimmermann 1, 2 , Gary M Brittenham 7
British Journal of Haematology ( IF 5.1 ) Pub Date : 2024-02-01 , DOI: 10.1111/bjh.19319 Ambra Giorgetti 1, 2 , Suzane Nyilima 3 , Nicole U Stoffel 1, 2 , Diego Moretti 4 , Edith Mwasi 5 , Simon Karanja 3 , Christophe Zeder 1 , Cornelia Speich 1 , Catalina Netland 1 , Zhezhen Jin 6 , Michael B Zimmermann 1, 2 , Gary M Brittenham 7
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Increased iron loss may reduce the effectiveness of iron supplementation. The objective of this study was to determine if daily oral iron supplementation increases iron loss, measured using a stable isotope of iron (58Fe). We enrolled and dewormed 24 iron-depleted Kenyan children, 24–27 months of age, whose body iron was enriched and equilibrated with 58Fe given at least 1 year earlier. Over 3 months of supplementation (6 mg iron/kg body weight [BW]/day), mean (±SD) iron absorption was 1.10 (±0.28) mg/day. During supplementation, 0.55 (±0.36) mg iron/day was lost, equal to half of the amount of absorbed iron. Supplementation did not increase faecal haem/porphyrin or biomarkers of enterocyte damage and gut or systemic inflammation. Using individual patient data, we examined iron dose, absorption and loss among all available long-term iron isotopic studies of supplementation. Expressed in terms of body weight, daily iron loss was correlated significantly with iron absorption (Pearson's r = 0.66 [95% confidence interval 0.48–0.78]) but not with iron dose (r = 0.16 [95% CI −0.10–0.40]). The results of this study indicate that iron loss is increased with daily oral iron supplementation and may blunt the efficacy of iron supplements in children. This study was registered at ClinicalTrials.gov as NCT04721964.
中文翻译：
对肯尼亚幼儿在补铁 3 个月期间进行的稳定铁 (58Fe) 同位素测量表明，吸收的铁有一半丢失了
铁损失增加可能会降低补铁的效果。本研究的目的是确定每日口服铁补充剂是否会增加铁损失，使用铁的稳定同位素（ 58 Fe）进行测量。我们招募了 24 名 24-27 个月大的缺铁肯尼亚儿童并进行了驱虫，他们的体内铁通过至少 1 年前给予的58 Fe 得到了丰富和平衡。补充 3 个月后（6 毫克铁/公斤体重 [BW]/天），平均 (±SD) 铁吸收量为 1.10 (±0.28) 毫克/天。补充期间，每天损失 0.55 (±0.36) 毫克铁，相当于吸收铁量的一半。补充剂不会增加粪便血红素/卟啉或肠细胞损伤和肠道或全身炎症的生物标志物。使用个体患者数据，我们检查了所有可用的长期铁同位素补充剂研究中的铁剂量、吸收和损失。以体重表示，每日铁损失与铁吸收显着相关（Pearson's r = 0.66 [95% 置信区间 0.48–0.78]），但与铁剂量无关（ r = 0.16 [95% CI -0.10–0.40]） 。这项研究的结果表明，每日口服铁补充剂会增加铁的流失，并可能削弱儿童铁补充剂的功效。该研究在 ClinicalTrials.gov 上注册为 NCT04721964。
更新日期：2024-02-02
中文翻译：
对肯尼亚幼儿在补铁 3 个月期间进行的稳定铁 (58Fe) 同位素测量表明，吸收的铁有一半丢失了
铁损失增加可能会降低补铁的效果。本研究的目的是确定每日口服铁补充剂是否会增加铁损失，使用铁的稳定同位素（ 58 Fe）进行测量。我们招募了 24 名 24-27 个月大的缺铁肯尼亚儿童并进行了驱虫，他们的体内铁通过至少 1 年前给予的58 Fe 得到了丰富和平衡。补充 3 个月后（6 毫克铁/公斤体重 [BW]/天），平均 (±SD) 铁吸收量为 1.10 (±0.28) 毫克/天。补充期间，每天损失 0.55 (±0.36) 毫克铁，相当于吸收铁量的一半。补充剂不会增加粪便血红素/卟啉或肠细胞损伤和肠道或全身炎症的生物标志物。使用个体患者数据，我们检查了所有可用的长期铁同位素补充剂研究中的铁剂量、吸收和损失。以体重表示，每日铁损失与铁吸收显着相关（Pearson's r = 0.66 [95% 置信区间 0.48–0.78]），但与铁剂量无关（ r = 0.16 [95% CI -0.10–0.40]） 。这项研究的结果表明，每日口服铁补充剂会增加铁的流失，并可能削弱儿童铁补充剂的功效。该研究在 ClinicalTrials.gov 上注册为 NCT04721964。
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