Circadian rhythms are daily cycles in physiology that can affect medical interventions. This review considers how these rhythms may relate to solid organ transplantation. It begins by summarizing the mechanism for circadian rhythm generation known as the molecular clock, and basic research connecting the clock to biological activities germane to organ acceptance. Next follows a review of clinical evidence relating time of day to adverse transplantation outcomes. The concluding section discusses knowledge gaps and practical areas where applying circadian biology might improve transplantation success.

中文翻译：

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实体器官移植中的昼夜节律

昼夜节律是生理学中的日常周期，可以影响医疗干预。本综述考虑了这些节律与实体器官移植的关系。首先总结了被称为分子钟的昼夜节律产生机制，以及将生物钟与与器官接受密切相关的生物活动联系起来的基础研究。接下来是对一天中的时间与不良移植结果相关的临床证据的审查。结论部分讨论了应用昼夜节律生物学可能提高移植成功率的知识差距和实践领域。