Journal of Cardiovascular Translational Research ( IF 2.4 ) Pub Date : 2024-02-01 , DOI: 10.1007/s12265-023-10476-5 Bas J Kersten 1 , Lieke Numan 2 , Marnix M van der Schoot 3 , Michel de Jong 4 , Faiz Ramjankhan 5 , Emmeke Aarts 6 , Marish I F J Oerlemans 2 , Linda W van Laake 2 , Eric E C de Waal 1
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Abstract
This study aims to associate the incidence of postoperative vasoplegia and short-term survival to the implantation of various left ventricular assist devices differing in hemocompatibility and flow profiles. The overall incidence of vasoplegia was 25.3% (73/289 patients) and 30.3% (37/122), 25.0% (18/72), and 18.9% (18/95) in the axial flow (AXF), centrifugal flow (CF), and centrifugal flow with artificial pulse (CFAP) group, respectively. Vasoplegia was associated with longer intensive care (ICU) and hospital length of stay (LOS) and mortality. ICU and in-hospital LOS and 1-year mortality were the lowest in the CFAP group. Post hoc analysis resulted in a p-value of 0.43 between AXF and CF; 0.35 between CF and CFAP; and 0.06 between AXF and CFAP. Although there is a trend in diminished incidence of vasoplegia, pooled logistic regression using flow profile and variables that remained after feature selection showed that flow profile was not an independent predictor for postoperative vasoplegia.
Graphical Abstract
中文翻译：
FLAVOR 研究：连续流左心室辅助装置植入后的流量曲线和术后血管麻痹
抽象的
本研究旨在将术后血管麻痹和短期生存的发生率与血液相容性和血流分布不同的各种左心室辅助装置的植入联系起来。血管麻痹的总体发生率为25.3%（73/289例患者），轴流（AXF）、离心流（ CF）和人工脉冲离心流（CFAP）组。血管麻痹与较长的重症监护（ICU）、住院时间（LOS）和死亡率相关。 CFAP 组的 ICU 和住院 LOS 以及 1 年死亡率最低。事后分析得出 AXF 和 CF 之间的p值为 0.43； CF与CFAP之间为0.35； AXF 和 CFAP 之间为 0.06。尽管血管麻痹发生率有减少的趋势，但使用血流剖面和特征选择后保留的变量进行的汇总逻辑回归表明，血流剖面并不是术后血管麻痹的独立预测因子。
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