As more is learned about the benefits of microbes, their potential to prevent and treat disease is expanding. Microbial therapeutics are less burdensome and costly to produce than traditional molecular drugs, often with superior efficacy. Yet, as with most medicines, controlled dosing and delivery to the area of need remain key challenges for microbes. Advances in materials to control small-molecule delivery are expected to translate to microbes, enabling similar control with equivalent benefits. In this perspective, recent advances in living biotherapeutics are discussed within the context of new methods for their controlled release. The integration of these advances provides a roadmap for the design, synthesis, and analysis of controlled microbial therapeutic delivery systems.

中文翻译：

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用于控制释放细菌治疗剂的新型递送系统


随着人们对微生物益处的了解越来越多，它们预防和治疗疾病的潜力正在扩大。与传统分子药物相比，微生物疗法的生产负担更轻，成本也更低，而且通常具有优越的功效。然而，与大多数药物一样，控制剂量和输送到需要的区域仍然是微生物面临的主要挑战。控制小分子输送的材料的进步预计将转化为微生物，从而实现类似的控制并带来同等的好处。从这个角度来看，活体生物治疗的最新进展是在其受控释放的新方法的背景下讨论的。这些进步的整合为受控微生物治疗递送系统的设计、合成和分析提供了路线图。