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Effects of polyol and surfactant plasticisers on lyophilised rice starch wafers for buccal drug delivery
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2024-02-02 , DOI: 10.1016/j.ijbiomac.2024.129935 Jing Yi Lee 1 , Li Wen Tan 1 , Kay Vien Lee 1 , Khi Poay Beh 2 , Choon Fu Goh 1
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2024-02-02 , DOI: 10.1016/j.ijbiomac.2024.129935 Jing Yi Lee 1 , Li Wen Tan 1 , Kay Vien Lee 1 , Khi Poay Beh 2 , Choon Fu Goh 1
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Rice starch is a promising biopolymer for buccal formulations but typical oven drying may promote starch retrogradation that affects mechanical properties. Hence, lyophilisation was proposed here to improve starch product's stability. This study aims to investigate the effects of plasticisers (sorbitol and Tween® 80, T80) on the characteristics and drug release profiles of lyophilised rice starch wafers incorporated with propranolol hydrochloride. The wafers were prepared by lyophilising starch mixture (5%/) with plasticiser (0.2 and 0.3 g/g) and drug (10, 20, 30%/w). Control wafers exhibited loose layers with rough wrinkled surface. Sorbitol resulted in a dense structure with higher puncture strength (PS) but lower water absorption capacity (WAC) while T80 loosened the flakes that reduced PS and increased WAC. Drug inclusion decreased PS and increased WAC of unplasticised wafers. T80-plasticised wafers with drug had a lower PS and higher WAC than sorbitol-plasticised wafers. Particularly, T80-plasticised wafers achieved outstandingly high PS and the lowest WAC at 30%/w drug. Drug dissolution of wafers relied mainly on the drug crystallinity and WAC at 10 and 30%/w drug. Plasticisers reduced and increased drug dissolution at 10 and 20%w/w drug, respectively. This study highlights the potential of lyophilisation in preparing rice starch wafers for buccal delivery.
中文翻译：
多元醇和表面活性剂增塑剂对冻干大米淀粉片口腔给药的影响
大米淀粉是一种很有前途的口腔制剂生物聚合物，但典型的烤箱干燥可能会促进淀粉回生，从而影响机械性能。因此，这里提出冻干来提高淀粉产品的稳定性。本研究旨在研究增塑剂（山梨糖醇和 Tween® 80、T80）对掺有盐酸普萘洛尔的冻干大米淀粉片的特性和药物释放曲线的影响。通过冻干淀粉混合物(5%/)与增塑剂(0.2和0.3 g/g)和药物(10、20、30%/w)来制备威化饼。对照晶片表现出松散的层和粗糙的皱纹表面。山梨醇导致致密结构，具有更高的穿刺强度 (PS)，但吸水能力 (WAC) 较低，而 T80 使薄片疏松，从而降低 PS 并增加 WAC。药物掺入降低了未塑化威化饼的 PS 并增加了 WAC。与山梨醇增塑威化饼相比，含有药物的 T80 增塑威化饼具有较低的 PS 和较高的 WAC。特别是，T80 增塑晶圆在 30%/w 药物浓度下实现了极高的 PS 和最低的 WAC。晶片的药物溶出主要取决于药物结晶度和WAC（10%/w 和30%/w 药物）。增塑剂分别在 10% 和 20%w/w 药物时减少和增加药物溶出。这项研究强调了冻干在制备用于口腔递送的大米淀粉薄饼中的潜力。
更新日期：2024-02-02
中文翻译：
多元醇和表面活性剂增塑剂对冻干大米淀粉片口腔给药的影响
大米淀粉是一种很有前途的口腔制剂生物聚合物，但典型的烤箱干燥可能会促进淀粉回生，从而影响机械性能。因此，这里提出冻干来提高淀粉产品的稳定性。本研究旨在研究增塑剂（山梨糖醇和 Tween® 80、T80）对掺有盐酸普萘洛尔的冻干大米淀粉片的特性和药物释放曲线的影响。通过冻干淀粉混合物(5%/)与增塑剂(0.2和0.3 g/g)和药物(10、20、30%/w)来制备威化饼。对照晶片表现出松散的层和粗糙的皱纹表面。山梨醇导致致密结构，具有更高的穿刺强度 (PS)，但吸水能力 (WAC) 较低，而 T80 使薄片疏松，从而降低 PS 并增加 WAC。药物掺入降低了未塑化威化饼的 PS 并增加了 WAC。与山梨醇增塑威化饼相比，含有药物的 T80 增塑威化饼具有较低的 PS 和较高的 WAC。特别是，T80 增塑晶圆在 30%/w 药物浓度下实现了极高的 PS 和最低的 WAC。晶片的药物溶出主要取决于药物结晶度和WAC（10%/w 和30%/w 药物）。增塑剂分别在 10% 和 20%w/w 药物时减少和增加药物溶出。这项研究强调了冻干在制备用于口腔递送的大米淀粉薄饼中的潜力。
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