Minimally invasive scar release by autologous adipose tissue transfer for post-traumatic neuropathic pain,Regenerative Therapy

当前位置： X-MOL 学术 › Regen. Ther. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Minimally invasive scar release by autologous adipose tissue transfer for post-traumatic neuropathic pain
Regenerative Therapy ( IF 3.4 ) Pub Date : 2024-02-01 , DOI: 10.1016/j.reth.2023.12.017
Giorgio Pietramaggiori _{1,

2} , Federico Ricci ₂ , Stefano L'Erario ₂ , Franco Bassetto ₂ , Saja Scherer _{1,

2}

Affiliation

Addressing post traumatic lower limb neuropathic pain is challenging across medical specialties. To address this potentially devastating condition, several invasive and non-invasive approaches have been proposed with inconsistent results. Adipose fat transfer (AFT), also known as fat grafting, is a regenerative medicine technique in which a patient's own fat is harvested from one area of the body (usually through liposuction) and then injected into another area for various purposes, such as aesthetic contour enhancement or reconstruction and regeneration of scarred tissues. We analyze the effects of fat grafting for neuropathic pain combined with neuroma excision (hybrid technique, hAFT) or alone (AFT). A retrospective review was conducted on 22 patients with neuropathic lower limb pain, after trauma or orthopedic surgery treated with hAFT (n = 9) or AFT (n = 13). Reduction in VAS scale more than 50 % was observed in 6 patients (66 %) treated with hybrid technique and in eleven patients (85 %) treated with AFT alone. Among these, complete pain reduction (>91 %) was achieved in 33.3 % of hAFT and 54 % of AFT technique. A 3.2 points reduction in VAS was found in the hAFT group versus 5.8 points in the AFT group (p = 0.035). This pioneering use of AFT emerges as a minimally invasive breakthrough, promising significant improvement in reconstructing scarred subcutaneous tissue and managing neuropathic pain.

中文翻译：

自体脂肪组织移植微创疤痕释放治疗创伤后神经性疼痛

解决创伤后下肢神经性疼痛对于医学专业来说是一个挑战。为了解决这种潜在的破坏性情况，已经提出了几种侵入性和非侵入性方法，但结果不一致。脂肪移植（AFT），也称为脂肪移植，是一种再生医学技术，从身体的一个区域（通常通过抽脂术）提取患者自身的脂肪，然后注射到另一个区域以用于各种目的，例如美容轮廓增强或疤痕组织的重建和再生。我们分析了脂肪移植联合神经瘤切除术（混合技术，hAFT）或单独治疗（AFT）对神经性疼痛的效果。对 22 名接受 hAFT (n = 9) 或 AFT (n = 13) 治疗的创伤或骨科手术后出现神经性下肢疼痛的患者进行了回顾性研究。在使用混合技术治疗的 6 名患者 (66%) 和仅使用 AFT 治疗的 11 名患者 (85%) 中观察到 VAS 评分减少了 50% 以上。其中，hAFT 技术的 33.3% 和 AFT 技术的 54% 实现了完全疼痛减轻（>91%）。 hAFT 组的 VAS 降低了 3.2 分，而 AFT 组则降低了 5.8 分 (p = 0.035)。 AFT 的这一开创性应用是一项微创突破，有望在重建疤痕皮下组织和控制神经性疼痛方面取得显着改善。

更新日期：2024-02-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南