<br>近红外光响应金纳米粒子涂层赋予聚醚醚酮增强的骨整合和抗菌性能,Materials Today Bio

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近红外光响应金纳米粒子涂层赋予聚醚醚酮增强的骨整合和抗菌性能
Materials Today Bio ( IF 8.7 ) Pub Date : 2024-02-01 , DOI: 10.1016/j.mtbio.2024.100982
Xinxin Zhan ₁ , Jianglong Yan ₂ , Dong Xiang ₁ , Hao Tang ₁ , Lulu Cao ₁ , Yufeng Zheng ₃ , Hong Lin ₁ , Dandan Xia ₁

Affiliation

聚醚醚酮（PEEK）由于其优异的物理化学和机械性能被认为是一种有前途的牙科种植材料。然而，其广泛的应用受到其生物惰性的限制。在这项研究中，含有金纳米粒子 (AuNP) 和甲硝唑的近红外 (NIR) 光响应生物活性涂层通过多巴胺聚合粘附到 PEEK 表面。与纯PEEK相比，处理后的PEEK表面亲水性显着提高。此外，在近红外光下，表面涂层表现出光热转换效应，金纳米颗粒和抗生素可以从涂层中释放出来。这提高了 PEEK 材料的抗菌性能。而且，涂层更有利于骨间充质干细胞的早期粘附。和成骨活性研究结果表明，所开发的涂层促进了PEEK种植体的骨整合，近红外光照射进一步提高了PEEK种植体的抗菌能力和成骨活性。通过RNA测序，解释了AuNPs涂层联合甲硝唑促进骨形成的潜在机制。总之，所开发的涂层是一种潜在的表面处理策略，赋予 PEEK 增强的骨整合和抗菌性能。

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Near-infrared light responsive gold nanoparticles coating endows polyetheretherketone with enhanced osseointegration and antibacterial properties

Polyetheretherketone (PEEK) is considered as a promising dental implant material owing to its excellent physicochemical and mechanical properties. However, its wide range of applications is limited by its biologically inert nature. In this study, a near-infrared (NIR) light responsive bioactive coating with gold nanoparticles (AuNPs) and metronidazole adhered to the PEEK surface via dopamine polymerization. Compared to pure PEEK, the hydrophilicity of the treated PEEK surface was significantly improved. In addition, under NIR light, the surface coating exhibited photothermal conversion effect, and gold nanoparticles and the antibiotic can be released from the coating. This improved the antibacterial properties of PEEK materials. Moreover, the coating was more conducive to the early adhesion of bone mesenchymal stem cells. The results of and osteogenic activity studies showed that the developed coating promoted osseointegration of PEEK implants, and NIR light irradiation further improved the antibacterial ability and osteogenic activity of PEEK implants. Through RNA sequencing, the potential underlying mechanism of promoting bone formation of the AuNPs coating combined metronidazole was interpreted. In summary, the developed coating is a potential surface treatment strategy that endows PEEK with enhanced osseointegration and antibacterial properties.

更新日期：2024-02-01

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