Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by . and , discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for understanding physiological modulation pathways and mutation-induced dysfunction and for designing potential drugs to modify defects.

中文翻译：

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揭示心肌粗丝的复杂结构

肌肉收缩是由众所周知的细肌丝和明显复杂的粗肌丝精心策划的。研究由 . 这里讨论的，以精致的近原子细节揭示了哺乳动物心脏粗丝的结构，并为理解生理调节途径和突变引起的功能障碍以及设计潜在的药物来修饰缺陷铺平了道路。