Journal of Sol-Gel Science and Technology ( IF 2.3 ) Pub Date : 2024-01-31 , DOI: 10.1007/s10971-024-06312-0
Amenah Al-barudi , Genada Sinani , Zeynep Ulker
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Tragacanth, an anionic polysaccharide, is a natural material widely investigated for the synthesis of aerogels as drug delivery vehicles. Its biocompatibility, biodegradability, and affordability are all key features for its use in pharmaceutical applications. In this study, tragacanth and tragacanth alginate composite aerogels were prepared using the sol-gel technique followed by supercritical drying. Paracetamol was selected as a model drug for drug loading and release studies owing to its high solubility in ethanol and low solubility in supercritical carbon dioxide. The paracetamol loading into the aerogel pores was confirmed by infrared spectroscopy (IR) and x-ray diffraction (XRD) spectra of the resulting samples. Scanning electron microscopy (SEM) images showed that all aerogels were porous with a macroporous-mesoporous network. Due to the high porosity of the prepared aerogels, a loading of 99 wt% (mg drug/mg aerogel) for tragacanth and 114 wt% (mg drug/mg aerogel) for composite aerogels was achieved. Moreover, the release rate of the drug could be modified by manipulating the aerogel composition. Tragacanth aerogels had a faster release rate, while the addition of alginate prolonged the release rate of the model drug. Various empirical release models were investigated and the release rate was found to follow the Korsmeyer-Peppas (Power Law) model suggesting a diffusion-based release kinetics. Based on the results, the feasibility of utilizing tragacanth for the preparation of drug-loaded aerogels was shown.
Graphical Abstract
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基于黄芪胶和海藻酸盐的可生物降解多糖气凝胶作为新型药物递送系统
黄芪胶是一种阴离子多糖,是一种广泛研究用于合成气凝胶作为药物输送载体的天然材料。其生物相容性、生物降解性和经济性都是其在制药应用中的关键特征。本研究采用溶胶-凝胶技术并通过超临界干燥制备了黄芪胶和黄芪胶海藻酸盐复合气凝胶。扑热息痛因其在乙醇中的高溶解度和在超临界二氧化碳中的低溶解度而被选为药物装载和释放研究的模型药物。通过所得样品的红外光谱 (IR) 和 X 射线衍射 (XRD) 光谱证实了对乙酰氨基酚负载到气凝胶孔中。扫描电子显微镜(SEM)图像显示所有气凝胶都是多孔的,具有大孔-介孔网络。由于所制备的气凝胶具有高孔隙率,黄芪胶的负载量为 99 wt%(mg 药物/mg 气凝胶),复合气凝胶的负载量为 114 wt%(mg 药物/mg 气凝胶)。此外,可以通过操纵气凝胶组合物来改变药物的释放速率。黄芪胶气凝胶具有更快的释放速率,而海藻酸盐的添加延长了模型药物的释放速率。研究了各种经验释放模型,发现释放速率遵循 Korsmeyer-Peppas(幂律)模型,表明基于扩散的释放动力学。研究结果表明利用黄芪胶制备载药气凝胶的可行性。