4-Aryl-4-oxo-2-(thiophen-2-ylamino)but-2-enoates bearing a cyano functional group at the thiophene ring were synthesized by the reaction of the corresponding substituted 3-(thiophen-2-ylamino)-3H-furan-2-ones with primary alcohols. Evaluation of biological activity and acute toxicity of the synthesized esters revealed their pronounced anti-inflammatory effect and low toxicity.

中文翻译：

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4-芳基-2-[(3-氰基噻吩-2-基)氨基]-4-氧代丁-2-烯酸酯的合成及抗炎活性

通过相应取代的3-(噻吩-2-基氨基)-的反应合成了在噻吩环上带有氰基官能团的4-芳基-4-氧代-2-(噻吩-2-基氨基)丁-2-烯酸酯。 3 H-呋喃-2-酮与伯醇。合成酯的生物活性和急性毒性评价表明其具有显着的抗炎作用和低毒性。