Abstract

A simple and convenient approach to the synthesis of the derivatives of unsymmetrical 1,1′-disubstituted cyclopropane-containing azinylferrocenes was suggested. A regioselective method for the Friedel—Crafts acylation of monoazinyl-substituted ferrocenes with a 4-chlorobutyryl chloride—AlCl₃ mixture in CH₂Cl₂ under an inert atmosphere was elaborated. The acylation product on treatment with Bu^tOK in DMSO readily underwent γ-elimination of HCl to give the corresponding cyclopropanes. The structures of the synthesized compounds were confirmed by IR spectroscopy, ¹H and ¹³C spectroscopy, mass spectrometry, and X-ray diffraction analysis.

中文翻译：

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不对称1,1'-二取代环丙烷含吖嗪基二茂铁的合成与结构

摘要

提出了一种简单方便的合成不对称1,1'-二取代环丙烷含吖嗪基二茂铁衍生物的方法。详细阐述了在惰性气氛下，在CH ₂ Cl ₂中，用4-氯丁酰氯-AlCl _{3混合物对单嗪基取代的二茂铁进行弗里德尔-克来福特酰化反应的区域选择性方法。}^{在 DMSO 中用 Bu t} OK处理的酰化产物很容易发生 HCl 的 γ-消除反应，得到相应的环丙烷。合成的化合物的结构通过红外光谱、^1H和^13C光谱、质谱和X射线衍射分析进行了确认。