Indole is a prestigious heterocyclic skeleton widely found in both naturally-occurring and biologically-active compounds. Pharmaceutical agents containing an indole skeleton in their framework possess a wide range of pharmacological properties, including antiviral, antitumor, analgesic, and other therapeutic activities, and many indole-containing drugs have been proven to have excellent pharmacokinetic and pharmacological effects. Over the past few decades, the FDA has approved over 40 indole-containing drugs for the treatment of various clinical conditions, and the development of indole-related drugs has attracted significant attention from medicinal chemists. This review aims to provide an overview of all the approved drugs that contain an indole nucleus, focusing on their targets, pharmacological activities, and SAR studies.

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含吲哚药物：靶标、药理活性和 SAR 研究

吲哚是一种著名的杂环骨架，广泛存在于天然存在的化合物和生物活性化合物中。骨架中含有吲哚骨架的药物具有广泛的药理特性，包括抗病毒、抗肿瘤、镇痛等治疗活性，并且许多含有吲哚的药物已被证明具有优异的药代动力学和药理作用。过去几十年来，FDA已批准了40多种含吲哚药物用于治疗各种临床病症，吲哚相关药物的开发引起了药物化学家的极大关注。本综述旨在概述所有已批准的含有吲哚核的药物，重点关注其靶点、药理活性和 SAR 研究。