: Alnustone (4(E)-,6(E)-1,7-Diphenyl-hepta-4,6-dien-3-one) is a non-phenolic natural diarylheptanoid, which was first isolated and identified from the male flower of Alnus pendula (Betulaceae). It can also be isolated from Curcuma xanthorrhiza Roxb (Zingiberaceae) rhizomes and Alpinia katsumadai Hayata (Zingiberaceae) seeds. It was first synthesized through a five-step process from β-phenyl propionyl chloride. In later years, new methods for synthesizing Alnustone were designed and performed with different yields. Due to the various therapeutic effects exhibited by alnustone like other diarylheptanoids, its biological activities such as antioxidant, antibacterial, and anti-inflammatory properties have been the subject of many studies. This article has reviewed different aspects of this valuable natural compound, including its natural and synthetic sources, therapeutic effects, and pharmacokinetics as a potential future therapeutic agent.

中文翻译：

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Alnustone：对其来源、药理学和药代动力学的回顾 ‏


：Alnustone (4(E)-,6(E)-1,7-Dipheny-hepta-4,6-dien-3-one) 是一种非酚类天然二芳基庚烷，首次从雄花中分离和鉴定桤木 (Alnus pendula) (桦木科)。也可从姜科姜黄根茎和姜科 Alpinia katsumadai Hayata 种子中分离得到。它首先由β-苯基丙酰氯通过五步法合成。在后来的几年里，人们设计并实施了合成Alnustone的新方法，并获得了不同的产率。由于阿努石与其他二芳基庚烷类化合物一样具有多种治疗作用，其抗氧化、抗菌和抗炎等生物活性已成为许多研究的主题。本文综述了这种有价值的天然化合物的不同方面，包括其天然和合成来源、治疗效果以及作为未来潜在治疗剂的药代动力学。