1,2-Dimethyl-3-methylsulfanylbenzene is the key intermediate of topramezone. This work designed a two-step continuous-flow device to synthesize 1,2-dimethyl-3- methylsulfanylbenzene via diazotization and methanethiolation. The results showed that compared with the batch process, the continuous-flow method greatly shortened the residence time to 1 minute, avoided the accumulation of large amounts of diazonium salts to reduce decomposition and increased the product yield to 91.7%. At the same time, the continuous- flow process improved the safety and efficiency of the reactions, saved reaction time and had good prospects for industrial application.

中文翻译：

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重氮化和甲硫基化两步连续流合成1,2-二甲基-3-甲硫基苯

1,2-二甲基-3-甲硫基苯是topramezone的关键中间体。本工作设计了一种两步连续流装置，通过重氮化和甲硫基化合成1,2-二甲基-3-甲硫基苯。结果表明，与间歇法相比，连续流法大大缩短了停留时间至1分钟，避免了大量重氮盐的积累，减少了分解，产品收率提高至91.7%。同时，连续流工艺提高了反应的安全性和效率，节省了反应时间，具有良好的工业应用前景。