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Iodine(III)-promoted oxidative carbotrifluoromethylation of maleimides with imidazopyridines and Langlois’ reagent
Chemical Communications ( IF 4.3 ) Pub Date : 2024-01-30 , DOI: 10.1039/d3cc05889a
Dipti Lai 1, 2 , Suvam Bhattacharjee 1 , Saurodeep Mandal 1 , Sumit Ghosh 1, 2 , Prithidipa Sahoo 1 , Subrata Sinha 2 , Alakananda Hajra 1
Affiliation  

A metal-free protocol for oxidative carbotrifluoromethylation of maleimides with imidazopyridines and Langlois’ reagent has been developed using (diacetoxyiodo)benzene (PIDA) as an oxidant. This three-component strategy enables one-step construction of 3,4-disubstituted maleimides in good yields with high functional group tolerance. Both experimental and theoretical studies support the proposed radical reaction mechanism.

中文翻译:


碘 (III) 促进的马来酰亚胺与咪唑并吡啶和 Langlois 试剂的氧化碳三氟甲基化



使用(二乙酰氧基碘)苯(PIDA)作为氧化剂,开发了一种用咪唑并吡啶和 Langlois 试剂对马来酰亚胺进行氧化碳三氟甲基化的无金属方案。这种三组分策略能够以良好的产率和高官能团耐受性一步构建 3,4-二取代马来酰亚胺。实验和理论研究都支持所提出的自由基反应机制。
更新日期:2024-01-30
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