<br>神秘的指环病毒：研究其在人类疾病中的作用,BMC Microbiology

当前位置： X-MOL 学术 › BMC Microbiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

神秘的指环病毒：研究其在人类疾病中的作用
BMC Microbiology ( IF 4.0 ) Pub Date : 2024-01-29 , DOI: 10.1186/s12866-024-03187-7
Mohammad Sabbaghian ₁ , Hamidreza Gheitasi ₁ , Ali Akbar Shekarchi ₂ , Ahmad Tavakoli ₃ , Vahdat Poortahmasebi _{1,

4}

Affiliation

感染人类的指环病毒 (AV) 是指环病毒科的成员。它们广泛分布于世界各地的人群中。托克特诺病毒 (TTV) 是该家族中第一个被识别的病毒，估计在 80-90% 的人群的血清中发现。在鉴定 TTV 后的一段时间，Torque teno mini 病毒 (TTMV) 和 Torque teno midi 病毒 (TTMDV) 也被鉴定并分类在该科中。自从识别出这些病毒以来，已经在人体的各种生物体液中检测到了这些病毒，包括血液和尿液，以及肝脏和肾脏等重要器官。它们可以通过输血、粪口接触以及可能的性交在人与人之间传播。最近对这些新引入的病毒的研究表明，尽管它们与人类疾病没有直接关系，但它们可能间接参与引发或加剧一些与人类相关的疾病和病毒感染。在这些疾病中，我们可以提到各种癌症、免疫系统疾病、病毒感染、肝炎和艾滋病。此外，它们可能使用它们编码的 microRNA (miRNA) 来履行这种合作作用。此外，近年来，增殖及其病毒载量（尤其是 TTV）的作用已被强调，以表明免疫功能低下者或接受器官移植者的免疫系统状态。在这里，我们回顾了这些病毒在针对人类的疾病中可能发挥的作用，并强调它们是需要进一步研究的重要病毒。这篇综述可以为研究人员提供新的见解。

"点击查看英文标题和摘要"

The mysterious anelloviruses: investigating its role in human diseases

Anelloviruses (AVs) that infect the human population are members of the Anelloviridae family. They are widely distributed in human populations worldwide. Torque teno virus (TTV) was the first virus of this family to be identified and is estimated to be found in the serum of 80–90% of the human population. Sometime after the identification of TTV, Torque teno mini virus (TTMV) and Torque teno midi virus (TTMDV) were also identified and classified in this family. Since identifying these viruses, have been detected in various types of biological fluids of the human body, including blood and urine, as well as vital organs such as the liver and kidney. They can be transmitted from person to person through blood transfusions, fecal-oral contact, and possibly sexual intercourse. Recent studies on these newly introduced viruses show that although they are not directly related to human disease, they may be indirectly involved in initiating or exacerbating some human population-related diseases and viral infections. Among these diseases, we can mention various types of cancers, immune system diseases, viral infections, hepatitis, and AIDS. Also, they likely use the microRNAs (miRNAs) they encode to fulfill this cooperative role. Also, in recent years, the role of proliferation and their viral load, especially TTV, has been highlighted to indicate the immune system status of immunocompromised people or people who undergo organ transplants. Here, we review the possible role of these viruses in diseases that target humans and highlight them as important viruses that require further study. This review can provide new insights to researchers.

更新日期：2024-01-29

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南