AbstractAfter more than 20 years of trials, a practical scalable approach to fluoro‐substituted bicyclo[1.1.1]pentanes (F‐BCPs) has been developed. The physicochemical properties of the F‐BCPs have been studied, and the core was incorporated into the structure of the anti‐inflammatory drug Flurbiprofen in place of the fluorophenyl ring.

中文翻译：

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氟取代双环[1.1.1]戊烷的实用且可扩展的方法

摘要经过 20 多年的试验，开发出了一种实用的可扩展的氟代双环[1.1.1]戊烷 (F-BCP) 方法。人们对F-BCP的理化性质进行了研究，并将其核心取代氟苯环纳入抗炎药物氟比洛芬的结构中。