The synthesis of ester compounds is of practical importance for many applications. In this work, we report that diethyl 4,4′-biphenyldicarboxylate can be directly synthesized by the interaction of titanium ethoxide (Ti(OEt)₄) and biphenyl-4,4′-dicarboxylic acid without the addition of solvent and catalyst. Further, such synthetic route has been demonstrated to be also suitable for the synthesis of other similar ester compounds like diethyl 2,2′-bipyridine-5,5′-dicarboxylate. The structure of obtained products is determined by single-crystal X-ray diffraction analysis. The unique method will provide new insight into the production of ester compounds.

酯化合物的合成对于许多应用具有实际重要性。在这项工作中，我们报道了4,4'-联苯二甲酸二乙酯可以通过乙醇钛(Ti(OEt) ₄ )和联苯-4,4'-二甲酸的相互作用直接合成，无需添加溶剂和催化剂。此外，该合成路线已被证明也适用于合成其他类似的酯化合物，如2,2'-联吡啶-5,5'-二甲酸二乙酯。通过单晶X射线衍射分析确定了所得产物的结构。这种独特的方法将为酯类化合物的生产提供新的见解。