Hormone therapy (HT) is important and frequently used both regarding replacement therapy (HRT) and gender affirming therapy (GAHT). While HRT has been effective in addressing symptoms related to hormone shortage, several side effects have been described. In this context, there are some studies that show increased cardiovascular risk. However, there are also studies reporting protective aspects of HT. Nevertheless, the exact impact of HT on cardiovascular risk and the underlying mechanisms remain poorly understood. This article explores the relationship between diverse types of HT and cardiovascular risk, focusing on mechanistic insights of the underlying hormones on platelet and leukocyte function as well as on effects on endothelial and adipose tissue cells.

激素疗法 (HT) 对于替代疗法 (HRT) 和性别肯定疗法 (GAHT) 都很重要且经常使用。虽然激素替代疗法可以有效解决与激素缺乏相关的症状，但也有一些副作用被描述。在这种情况下，有一些研究表明心血管风险增加。然而，也有研究报告了 HT 的保护作用。然而，HT 对心血管风险的确切影响及其潜在机制仍知之甚少。本文探讨了不同类型的 HT 与心血管风险之间的关系，重点关注潜在激素对血小板和白细胞功能以及对内皮和脂肪组织细胞影响的机制见解。