Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies,ChemMedChem

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Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies
ChemMedChem ( IF 3.6 ) Pub Date : 2024-01-26 , DOI: 10.1002/cmdc.202300656
Bobby Lucero ₁ , Karol R Francisco _{1,

2} , Carmine Varricchio ₃ , Lawrence J Liu _{1,

2} , Yuemang Yao ₄ , Andrea Brancale ₅ , Kurt R Brunden ₄ , Conor R Caffrey ₂ , Carlo Ballatore ₂

Affiliation

We describe here the design, synthesis and evaluation of an anti-trypanosomal 1,2,4-triazolo[1,5-a]pyrimidine (TPD) probe which facilitated the design and execution of PAL experiments in whole HEK293 cells and T. brucei parasites. These experiments confirmed tubulin as a protein target in both HEK293 cells and T. brucei.

中文翻译：

用于光亲和标记研究的抗锥虫[1,2,4]三唑并[1,5-a]嘧啶探针的设计、合成和评估

我们在此描述了抗锥虫 1,2,4-三唑并[1,5- a ]嘧啶 (TPD) 探针的设计、合成和评估，该探针有助于在整个 HEK293 细胞和布氏锥虫中设计和执行 PAL 实验寄生虫。这些实验证实微管蛋白是 HEK293 细胞和布氏锥虫中的蛋白质靶标。

更新日期：2024-01-26

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