Copper-Catalyzed Enantioselective C(sp3)−SCF3 Coupling of Carbon-Centered Benzyl Radicals with (Me4N)SCF3,Angewandte Chemie International Edition

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Copper-Catalyzed Enantioselective C(sp3)−SCF3 Coupling of Carbon-Centered Benzyl Radicals with (Me4N)SCF3
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-01-26 , DOI: 10.1002/anie.202319850
Wei Zhang _{1,

2} , Yu Tian _{1,

2} , Xiao-Dong Liu _{1,

2} , Cheng Luan _{1,

2} , Ji-Ren Liu _{1,

2} , Qiang-Shuai Gu ₃ , Zhong-Liang Li ₄ , Xin-Yuan Liu _{1,

2}

Affiliation

A copper-catalyzed enantioselective radical C(sp³)−SCF₃ coupling of secondary/tertiary benzyl radicals with the easily available (Me₄N)SCF₃ reagent was developed to afford enantioenriched trifluoromethylthiolated molecules. The key to the success lies in the utilization of chiral phosphino-oxazoline-derived anionic N,N,P-ligands for the reaction initiation and enantioselectivity.

中文翻译：

铜催化碳中心苄基与 (Me4N)SCF3 的对映选择性 C(sp3)−SCF3 偶联

开发了铜催化的对映选择性自由基 C(sp ³ )−SCF ₃仲/叔苄基自由基与容易获得的 (Me ₄ N)SCF ₃试剂的偶联，以提供对映体富集的三氟甲基硫醇化分子。成功的关键在于利用手性膦基恶唑啉衍生的阴离子N,N,P-配体来引发反应并提高对映选择性。

更新日期：2024-01-26

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